Extended regimens of the contraceptive vaginal ring - A randomized trial
Extended regimens of the contraceptive vaginal ring - A randomized trial
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DOI：
10.1097/01.aog.0000175144.08035.74
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发表时间：
2005-09-01
影响因子：
7.2
通讯作者：
in't Hout, J
中科院分区：
文献类型：
--
作者：
Miller, L;Verhoeven, CHJ;in't Hout, J
目的：比较3种不同的延长环方案与标准28天周期的出血模式和耐受性，其中21天使用避孕阴道环，随后7天无环day.Methods：在28天的环周期运行后，妇女被随机分配到4种方案中的1种：每月（28天周期）、每隔一个月（49天周期）、每三个月（91天周期）或连续（364天周期）。治疗持续时间为1年。每日出血日记，间隔访视问卷调查，和检查data.Results：共561名妇女参加，429随后随机，289（67.4%）妇女完成了全年。所有的时间表都是耐受性好，可以接受的妇女，但研究完成率较高的较短的周期。出血天数减少，推迟撤退出血（环）周，但发现天增加。例如，使用连续或364天环周期的妇女报告了零出血天数的中位数，但在延长使用的前3个月内有10-12天的出血。传统的28天周期中，使用环期间的计划外出血最低。不良事件，血压，体重和实验室检查结果是可比的4个治疗groups.Conclusion：组合阴道避孕环可用于延长周期，改变出血时间表。愿意忍受一些斑点的女性可能会选择更长的延长时间来减少月经周期。
Objective: To compare the bleeding patterns and tolerability of 3 different extended ring regimens with those of the standard 28-day cycle with 21 days of contraceptive vaginal ring use followed by 7 ring-free days.Methods: Following a run-in 28-day ring cycle, women were randomized to 1 of 4 regimens: monthly (28-day cycle), every other month (49-day cycle), every third month (91-day cycle), or continuous (364-day cycle). Treatment duration was 1 year. Daily bleeding diary, interval visit questionnaire, and examination data were collected.Results: A total of 561 women were enrolled, 429 were subsequently randomized, and 289 (67.4%) women completed the entire year. All schedules were well tolerated and acceptable to women, but study completion rates were higher for the shorter cycles. Bleeding days were reduced with postponement of the withdrawal bleeding (ring-free) week, but spotting days increased. For example, women using the continuous or 364-day ring cycle reported a median of zero bleeding days but 10-12 days of spotting during the first 3 months of extended use. Unscheduled bleeding during ring use was the lowest with the traditional 28-day cycle. Adverse events, blood pressure, body weight, and laboratory findings were comparable over the 4 treatment groups.Conclusion: The combination vaginal contraceptive ring can be used for extended cycles to alter the bleeding schedule. Women willing to tolerate some spotting might choose the longer extensions to have fewer menstrual periods.