B cells in early and chronic HIV infection: evidence for preservation of immune function associated with early initiation of antiretroviral therapy
B cells in early and chronic HIV infection: evidence for preservation of immune function associated with early initiation of antiretroviral therapy
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DOI：
10.1182/blood-2010-05-285528
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发表时间：
2010-12-16
期刊：
影响因子：
20.3
通讯作者：
Fauci, Anthony S.
中科院分区：
文献类型：
--
作者：
Moir, Susan;Buckner, Clarisa M.;Fauci, Anthony S.
早期与慢性 HIV 感染期间淋巴细胞（包括 B 细胞）的特征对于了解慢性病毒血症对免疫细胞功能的影响非常重要。在这种情况下，我们研究了通过抗逆转录病毒疗法 (ART) 减少 HIV 血浆病毒血症前后的 B 细胞。在基线时，与未感染的对照组相比，早期和慢性 HIV 感染者的外周血 B 细胞计数显着较低。 ART 后，两组 B 细胞数量均显着增加，与 CD4(+) T 细胞类似，但与 CD8(+) T 细胞不同。在基线时，与早期感染者相比，早期 HIV 感染者的 B 细胞由更高比例的浆母细胞和静息记忆 B 细胞组成，慢性 HIV 感染者的 B 细胞由更高比例的未成熟/过渡和耗尽的 B 细胞组成。 ART 后 1 年，与慢性 HIV 感染者相比，早期静息记忆 B 细胞的百分比仍然较高。这种差异转化为更好的功能特征，因为与长期治疗的 HIV 感染者相比，早期记忆 B 细胞对 HIV 和非 HIV 抗原的反应优于长期治疗的个体。这些发现为 HIV 感染中的 B 细胞以及早期开始 ART 如何预防不可逆的免疫系统损伤提供了新的见解。 （血。2010；116（25）：5571-5579）
Characterization of lymphocytes including B cells during early versus chronic HIV infection is important for understanding the impact of chronic viremia on immune cell function. In this setting, we investigated B cells before and after reduction of HIV plasma viremia by antiretroviral therapy (ART). At baseline, peripheral blood B-cell counts were significantly lower in both early and chronic HIV-infected individuals compared with uninfected controls. Similar to CD4(+) but not CD8(+) T cells, B-cell numbers in both groups increased significantly after ART. At baseline, B cells of early HIV-infected individuals were composed of a higher percentage of plasmablasts and resting memory B cells compared with chronic HIV-infected individuals whose B cells were composed of a higher percentage of immature/transitional and exhausted B cells compared with their early infection counterparts. At 1 year after ART, the percentage of resting memory B cells remained higher in early compared with chronic HIV-infected individuals. This difference translated into a better functional profile in that memory B-cell responses to HIV and non-HIV antigens were superior in early-compared with chronic-treated HIV infected individuals. These findings provide new insights on B cells in HIV infection and how early initiation of ART may prevent irreversible immune system damage. (Blood. 2010; 116(25): 5571-5579)