THE SEVERITY OF COPPER DEFICIENCY IN RATS IS DETERMINED BY THE TYPE OF DIETARY CARBOHYDRATE
THE SEVERITY OF COPPER DEFICIENCY IN RATS IS DETERMINED BY THE TYPE OF DIETARY CARBOHYDRATE
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DOI：
10.3181/00379727-175-41832
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发表时间：
1984-01-01
影响因子：
--
通讯作者：
SMITH, JC
中科院分区：
文献类型：
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作者：
FIELDS, M;FERRETTI, RJ;SMITH, JC
研究了铜和膳食碳水化合物之间的相互作用对与铜缺乏相关的临床和酶指标的影响。通过喂养含有包括Se和Cr在内的所有营养物的充足饮食，但含有62%淀粉、果糖或葡萄糖的微量Cu（1.2 μ g/g饮食），在大鼠中产生Cu缺乏症。在第5周，果糖的铜缺乏饮食（20只大鼠）被取代的淀粉（10只大鼠）或葡萄糖（10只大鼠）。11 wk后终止实验。与喂淀粉或葡萄糖的大鼠相比，喂果糖的大鼠中铜缺乏显著降低体重和红细胞压积，但增加肝脏重量、血尿素、N、NH3、胆固醇和甘油三酯。铜金属酶，超氧化物歧化酶，硒酶，谷胱甘肽过氧化物酶和肝ATP的铜缺乏大鼠喂养果糖相比，铜缺乏大鼠喂养淀粉或葡萄糖。果糖可能是对铜和硒状况有有害影响的膳食成分。改变铜缺乏大鼠的饮食碳水化合物的类型，从果糖到淀粉或葡萄糖，改善了缺乏的严重程度。淀粉的保护作用比葡萄糖更明显。
The interaction between Cu and dietary carbohydrates on clinical and enzymatic indices associated with Cu deficiency was studied. Cu deficiency was produced in rats by feeding diets adequate in all nutrients including Se and Cr, but marginal in Cu (1.2 .mu.g/g diet) containing 62% of either starch, fructose, or glucose. During the 5th wk, the fructose of the Cu-deficient diet (20 rats) was replaced by either starch (10 rats) or by glucose (10 rats). The experiment was terminated after 11 wk. Cu deficiency in rats fed fructose significantly lowered body weight and hematocrit, but increased liver weight, blood urea, N, NH3, cholesterol and triglycerides when compared to rats fed starch or glucose. The Cu metalloenzyme, superoxide dismutase, the selenoenzyme, glutathione peroxidase and hepatic ATP were decreased in the Cu-deficient rats fed fructose as compared to Cu-deficient rats fed starch or glucose. Fructose may be the dietary component which has a deleterious effect on Cu and Se status. Changing the type of dietary carbohydrate in Cu-deficient rats from fructose to either starch or glucose ameliorated the severity of the deficiency. The protective effects were more pronounced with starch than with glucose.