Synovial permeability in rheumatoid arthritis.
Synovial permeability in rheumatoid arthritis.
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类风湿性关节炎的滑膜通透性。
DOI：
10.1002/art.1780220701
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发表时间：
1979
影响因子：
--
通讯作者：
J. Pizzorno
中科院分区：
文献类型：
--
作者：
Peter A. Simkin;J. Pizzorno
在类风湿关节炎患者和其他类型滑膜炎患者中，蛋白质进入膝关节的速度比正常人更快(P<0.001)。然而，类风湿滑膜对小分子(氚水，P<0.02；尿酸盐，P<0.05；葡萄糖，P<0.002)的渗透性低于正常关节衬里。这种差异的原因是类风湿性微血管改变增强了滑膜对蛋白质的通透性，而共存的间质变化降低了滑膜对小分子的通透性。
In patients with rheumatoid arthritis, as well as in persons with other kinds of synovitis, proteins enter the knee joint more rapidly than in normal individuals (P less than 0.001). The rheumatoid synovium, however, is less permeable to small molecules (tritiated water, P less than 0.02; urate, P less than 0.05; and glucose, P less than 0.002) than is the normal joint lining. This difference is explained if rheumatoid microvascular changes enhance synovial permeability to proteins while coexisting interstitial changes diminish synovial permeability to smaller molecules.