Prognostic significance of modal DNA value and other factors in malignant tumours, based on 1465 cases.
Prognostic significance of modal DNA value and other factors in malignant tumours, based on 1465 cases.
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DOI：
10.1038/bjc.1979.168
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发表时间：
1979-08
影响因子：
8.8
通讯作者：
Kay, R
中科院分区：
文献类型：
--
作者：
Atkin, N B;Kay, R
使用回归模型，1465 个肿瘤的模式 DNA 值以及可能具有重要预后意义的其他因素与患者的生存相关（Kay，1977）。对于除睾丸外的大多数肿瘤部位，模式 DNA 值的分布是双峰的，峰值出现在二倍体水平和三倍体-四倍体范围内。对于除子宫颈以外的所有肿瘤部位，低（近二倍体）范围内的患者表现出更好的生存率；子宫颈鳞状细胞癌的情况正好相反。其他变量显示出以下影响：对于除睾丸之外的所有部位，年轻患者表现出更好的生存率；对于子宫颈和子宫体、乳房和卵巢，临床分期的增加与较差的生存率相关。在评估中，组织学分级似乎与生存率相关，分化程度较低的肿瘤预后较差，但乳腺除外，其中注意到相反的相关性。对于膀胱癌，女性的生存率比男性差。
The modal DNA values of 1465 tumours, together with other factors of possible prognostic importance, were related to the survival of the patients, using regression models (Kay, 1977). For most tumour sites except the testis, the distributions of modal DNA values were bimodal, with peaks at the diploid level and in the triploid-tetraploid range. For all tumour sites except the cervix uteri, patients in the low (near-diploid) range showed better survival; the reverse was true for squamous-cell carcinoma of the cervix uteri. Other variables showed the following effects: for all sites except the testis, younger patients showed a better survival; for the cervix and corpus uteri, breast and ovary, increasing clinical stage was associated with poorer survival. Where evaluated, histological grade appeared to be associated with survival rate, the less well differentiated tumours having a worse prognosis, except for the breast, where the reverse correlation was noted. For carcinoma of the bladder, females and a poorer survival rate than males.