The Association between Retinal Vessel Diameter and Retinal Nerve Fiber Layer Thickness in Asymmetric Normal Tension Glaucoma Patients
The Association between Retinal Vessel Diameter and Retinal Nerve Fiber Layer Thickness in Asymmetric Normal Tension Glaucoma Patients
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DOI：
10.1167/iovs.12-9783
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发表时间：
2012-08-01
影响因子：
4.4
通讯作者：
Caprioli, Joseph
中科院分区：
文献类型：
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作者：
Kim, Joon Mo;Kim, Mo Sae;Caprioli, Joseph
目的。本研究的目的是评估正常眼压性青光眼 (NTG) 患者视网膜血管直径与视网膜神经纤维层 (RNFL) 厚度之间的关联。这项研究包括 67 名未经治疗的不对称 NTG 患者（对侧眼没有青光眼证据）和 48 名年龄和性别匹配的正常对照受试者。我们纳入的患者年龄在 20 至 70 岁之间，没有高血压、糖尿病或其他血管疾病史。所有受试者均接受了详细的眼科检查，包括无红光摄影、立体视盘摄影、自动视野检查以及光学相干断层扫描 RNFL 厚度测量。我们使用计算机辅助成像软件比较了 RNFL 厚度、颞部视网膜小动脉直径 (TRAD) 和颞部视网膜小静脉直径（有和没有 RNFL 缺陷的象限之间）。 结果。 NTG 患者有 RNFL 缺陷象限的颞部视网膜血管平均直径显着小于无 RNFL 缺陷象限的患者 (P < 0.001) 和对照受试者 (P < 0.001)。在二元逻辑回归分析和多元线性回归分析中（P < 0.001），TRAD 与 RNFL 缺陷和 RNFL 厚度相关（P < 0.05）。对照受试者的血管直径与受影响的 NTG 眼睛的无缺陷象限或 NTG 患者未受影响的眼睛的血管直径之间没有统计学上的显着差异。结论。我们的结果表明，RNFL 缺损区域的视网膜血管较窄。考虑到之前的报告和我们的分析，这可能是由于视网膜受损区域对视网膜血流的需求减少所致。 （投资眼科可见科学。2012 年；53：5609-5614）DOI：10.1167/iovs.12-9783
PURPOSE. The aim of this study was to evaluate the associations between retinal vessel diameter and retinal nerve fiber layer (RNFL) thickness in patients with normal tension glaucoma (NTG).METHODS. This study included 67 untreated patients with asymmetric NTG, with no evidence of glaucoma in the contralateral eyes, and 48 age-and sex-matched normal control subjects. We included patients from 20 to 70 years of age who had no history of hypertension, diabetes, or other vascular diseases. All subjects underwent detailed eye examinations that included red-free photography, stereoscopic optic disc photography, automated perimetry, and measurement of RNFL thickness with optical coherence tomography. We compared RNFL thicknesses, temporal retinal arteriolar diameters (TRAD), and temporal retinal venular diameters (between quadrants with and without RNFL defects) with computer-assisted imaging software.RESULTS. The mean diameter of the temporal retinal vessels in the quadrants with RNFL defects were significantly smaller in patients with NTG than in those with quadrants without RNFL defects (P < 0.001) and in control subjects (P < 0.001). TRADs were correlated with RNFL defects and RNFL thicknesses (P < 0.05) in binary logistic regression analysis and in multiple linear regression analysis (P < 0.001). There were no statistically significant differences between vessel diameters in control subjects and those in nondefective quadrants of the affected NTG eyes or the unaffected eyes of patients with NTG.CONCLUSIONS. Our results show that narrower retinal vessels are found in areas of RNFL defects. Considering previous reports and our analysis, this is likely due to the decreased demand for retinal blood flow in damaged areas of the retina. (Invest Ophthalmol Vis Sci. 2012;53:5609-5614) DOI:10.1167/iovs.12-9783