Ullmann diaryl ether synthesis: Rate acceleration by 2,2,6,6-tetramethylheptane-3,5-dione
Ullmann diaryl ether synthesis: Rate acceleration by 2,2,6,6-tetramethylheptane-3,5-dione
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DOI：
10.1021/ol025839t
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发表时间：
2002-05-02
期刊：
影响因子：
5.2
通讯作者：
Reider, PJ
中科院分区：
文献类型：
--
作者：
Buck, E;Song, ZJ;Reider, PJ
在铜盐催化芳基溴化物或碘化物与苯酚形成醚的过程中，2,2,6,6-四甲基庚烷-3,5-二酮（TMHD）被发现可以大大加速通常困难的反应，使其在更适中的温度和反应时间下发生。以NMP为溶剂，以碳酸铯为碱，以CuCl和TMHD为催化剂，一系列芳基卤化物和苯酚可形成醚。该反应可耐受富电子芳基溴和电子中性酚。
In the copper salt catalyzed ether formation from aryl bromides or iodides and phenols, 2,2,6,6-tetramethylheptane-3,5-dione (TMHD) was found to greatly accelerate the ordinarily difficult reaction, making it occur under more moderate temperatures and reaction times. A series of aryl halides and phenols were shown to form ethers in NMP as the solvent, cesium carbonate as the base, and CuCl and TMHD as the catalysts. The reaction was shown to tolerate electron-rich aryl bromides and electron-neutral phenols.