Smad6 Suppresses the Growth and Self-Renewal of Hepatic Progenitor Cells
Smad6 Suppresses the Growth and Self-Renewal of Hepatic Progenitor Cells
复制标题
Smad6 抑制肝祖细胞的生长和自我更新
DOI：
10.1002/jcp.24488
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发表时间：
2014-05-01
影响因子：
5.6
通讯作者：
Chen, Xiao-Ping
中科院分区：
文献类型：
--
作者：
Ding, Ze-Yang;Liang, Hui-Fang;Chen, Xiao-Ping
Activation of hepatic progenitor cells (HPCs) is commonly observed in chronic liver disease and Wnt/-catenin signaling plays a crucial role in the expansion of HPCs. However, the molecular mechanisms that regulate the activation of Wnt/-catenin signaling in the liver, especially in HPCs, remain largely elusive. Here, we reported that ectopic expression of Smad6 suppressed the proliferation and self-renewal of WB-F344 cells, a HPC cell line. Mechanistically, we found that Smad6 inhibited Wnt/-catenin signaling through promoting the interaction of C-terminal binding protein (CtBP) with -catenin/T-cell factor (TCF) complex to inhibit -catenin mediated transcriptional activation in WB-F344 cells. We used siRNA targeting -catenin to demonstrate that Wnt/-catenin signaling was required for the proliferation and self-renewal of HPCs. Taken together, these results suggest that Smad6 is a regulatory molecule which regulates the proliferation, self-renewal and Wnt/-catenin signaling in HPCs. J. Cell. Physiol. 229: 651-660, 2014. (c) 2013 Wiley Periodicals, Inc.
