Optical Coherence Tomography in the Eyes of Normal Children
Optical Coherence Tomography in the Eyes of Normal Children
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DOI：
10.1001/archophthalmol.2008.553
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发表时间：
2009-01-01
影响因子：
--
通讯作者：
Freedman, Sharon F.
中科院分区：
文献类型：
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作者：
El-Dairi, Mays A.;Asrani, Sanjay G.;Freedman, Sharon F.
目的：利用光学相干断层扫描(OCT)建立3~17岁儿童正常眼黄斑厚度、视网膜神经纤维层(RNFL)厚度和视神经地形图的标准数据库。每个孩子都进行了扩眼检查，使用IOL Master(Carl Zeiss Meditec，加利福尼亚州都柏林)进行眼轴长度测量，并使用Stratus OCT的快速黄斑映射图、快速RNFL厚度和快速视盘方案进行OCT测量(10月3日；Carl Zeiss Meditec)。结果：与白人儿童相比，黑人儿童的黄斑体积和中心凹厚度更小，RNFL厚度更大，杯盘面积比更大。在白人儿童中，黄斑体积和平均外黄斑厚度与眼轴长度呈负相关。只有黑人儿童的黄斑中心凹厚度与年龄呈正相关。只有白人儿童的平均RNFL与眼轴长度呈负相关(P<；所有儿童均为0.05)。所有变量的标准数据都被记录下来，并与报道的成人值进行比较。结论：在健康儿童中，层OCT-3测量的黄斑和RNFL厚度以及视神经地形图随种族、眼轴长度和年龄而变化。标准化的儿科OCT数据应该有助于使用OCT评估儿童青光眼和其他疾病。
Objective: To collect a normative database of macular thickness, retinal nerve fiber layer (RNFL) thicknesses, and optic nerve topography in the healthy eyes of children aged 3 to 17 years using optical coherence tomography (OCT) measurements.Methods: Scans were obtained for 286 healthy children (black, 114; white, 154; other, 18). Each child had a dilated eye examination, an axial length measurement using the IOL Master (Carl Zeiss Meditec, Dublin, California), and OCT measurements using the fast macular map, fast RNFL thickness, and fast optic disc protocols of the Stratus OCT (OCT-3; Carl Zeiss Meditec).Results: Black children had smaller macular volume and foveal thickness, larger RNFL thickness, and larger cupdisc area ratios compared with white children. Macular volume and average outer macular thickness correlated negatively with axial length in white children. Foveal thickness correlated positively with age in black children only. Average RNFL correlated negatively with axial length in white children only (P < .05 for all). Normative data for all variables were recorded and compared with reported adult values.Conclusions: Stratus OCT-3 measurements of macular and RNFL thickness and optic nerve topography vary with race, axial length, and age in healthy children. Normative pediatric OCT data should facilitate the use of OCT in assessing childhood glaucoma and other diseases.