Telornere length is paternally inherited and is associated with parental lifespan
Telornere length is paternally inherited and is associated with parental lifespan
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DOI：
10.1073/pnas.0702703104
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发表时间：
2007-07-17
影响因子：
11.1
通讯作者：
Hsueh, Wen-Chi
中科院分区：
文献类型：
--
作者：
Njajou, Omer T.;Cawthon, Richard M.;Hsueh, Wen-Chi
端粒长度（TL）正在成为衰老和生存的生物标志物。为了评估影响这一性状的因素，我们在一个大的同质群体中测量了TL，估计了遗传力（h（2）），并测试了亲本对TL变异的影响。我们的样本包括356名男性和551名女性，年龄在18-92岁之间，来自阿米什大家庭。通过定量PCR测量白细胞中的平均TL（平均值：6，198 +/-1，696 bp）。校正年龄、性别和TL检测批次后，TL的h（2）为0.44 ± 0.06（P < 0.001），0。TL与年龄呈负相关（r = -0.40; P < 0.001）。男性和女性之间的TL没有显著差异，这与我们之前的研究结果一致，即阿米什男性和阿米什女性寿命一样长。子代TL与父亲TL之间的相关性（r = 0.46，P < 0.001; 13 = 0.22，β = 0.006）强于子代TL与母亲TL之间的相关性（r = 0.18，P = 0.04; β =-0.02，P = 0.4）。此外，我们观察到女儿的TL与父亲寿命之间存在正相关和关联（r = 0.20，P < 0.001; β = 0.21，P = 0.04），但女儿的TL与母亲寿命之间没有相关性（r =-0.01，β = 0.04;两者P均不显著）。我们的数据，这是基于人类TL的最大的家庭研究之一，支持TL和衰老和寿命之间的联系，并建议一个强大的遗传影响，可能通过印迹机制，TL调节。
Telomere length (TL) is emerging as a biomarker for aging and survival. To evaluate factors influencing this trait, we measured TL in a large homogeneous population, estimated the heritability (h(2)), and tested for parental effects on TL variation. Our sample included 356 men and 551 women, aged 18-92 years, from large Amish families. Mean TL in leukocytes was measured by quantitative PCR (mean: 6,198 +/- 1,696 bp). The h(2) of TL was 0.44 +/- 0.06 (P < 0.001),0 after adjusting for age, sex, and TL assay batch. As expected, TL was negatively correlated with age (r = -0.40; P < 0.001). There was no significant difference in TL between men and women, consistent with our previous findings that Amish men lived as long as Amish women. There was a stronger and positive correlation and association between TL in the offspring and paternal TL (r = 0.46, P < 0.001; 13 = 0.22, beta = 0.006) than offspring and maternal TL (r = 0.18, P = 0.04; beta = -0.02, P = 0.4). Furthermore, we observed a positive correlation and association between daughter's TL and paternal lifespan (r = 0.20, P < 0.001; beta = 0.21, P = 0.04), but not between daughter's TL and maternal lifespan (r = -0.01, beta = 0.04; both P = not significant). Our data, which are based on one of the largest family studies of human TL, support a link between TL and aging and lifespan and suggest a strong genetic influence, possibly via an imprinting mechanism, on TL regulation.