Systemic Lupus Erythematosus Syndrome Induced by Practolol
Systemic Lupus Erythematosus Syndrome Induced by Practolol
复制标题
普乐洛尔诱发系统性红斑狼疮综合征
作者：
E. Raftery;A. Denman
三名心绞痛患者接受不同剂量的普萘洛尔治疗后出现关节痛综合征，特别是手部小关节，皮疹，发热，E.S.R.升高，和红斑狼疮（L.E.）的阳性检测细胞和抗核抗体。该综合征对停药有部分反应，但需要类固醇来产生足够的症状改善。这些疾病特征表明这是药物诱导的系统性红斑狼疮（S.L.E.）的一个例子。这些患者的淋巴细胞在体外转化能力受损表明了该综合征发病机制的可验证假设。
Three patients with angina pectoris treated with practolol in varying doses developed a syndrome of arthralgia, particularly of the small joints of the hands, rash, fever, a raised E.S.R., and positive tests for lupus erythematosus (L.E.) cells and antinuclear antibody. The syndrome responded partly to withdrawal of the drug, but steroids were required to produce adequate symptomatic improvement. These disease features suggest that this is an example of drug-induced systemic lupus erythematosus (S.L.E.). The impaired ability of lymphocytes from these patients to transform in vitro indicates a testable hypothesis for the pathogenesis of the syndrome.