Meniscal tear in knees without surgery and the development of radiographic osteoarthritis among middle-aged and elderly persons: The Multicenter Osteoarthritis Study.
Meniscal tear in knees without surgery and the development of radiographic osteoarthritis among middle-aged and elderly persons: The Multicenter Osteoarthritis Study.
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DOI：
10.1002/art.24383
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发表时间：
2009-03
影响因子：
--
通讯作者：
Felson, David T.
中科院分区：
文献类型：
--
作者：
Englund, Martin;Guermazi, Ali;Roemer, Frank W.;Aliabadi, Piran;Yang, Mei;Lewis, Cora E.;Torner, James;Nevitt, Michael C.;Sack, Burton;Felson, David T.
虽然半月板部分切除术是发生膝骨关节炎（OA）的危险因素，但缺乏证据表明半月板损伤不经手术治疗也会导致OA，这表明手术本身可能导致关节损伤。此外，半月板损伤是常见的。本研究的目的是评估未手术的膝关节半月板损伤与放射学胫骨股骨骨关节炎的发展之间的关系。我们在观察性多中心骨关节炎研究中进行了一项前瞻性病例对照研究，其中包括从社区招募的年龄在50-79岁的膝关节OA高风险男性和女性样本。在30个月的随访期间，没有基线放射照相膝部OA但出现胫骨股骨OA的患者为病例（n = 121）。对照组（n = 294）从与病例相同的人群中随机抽取，但随访30个月后无膝关节OA。此前曾做过膝盖手术的人被排除在外。半月板损伤定义为任何内侧或外侧半月板撕裂、浸渍或破坏。膝关节半月板损伤在基线时比对照组更常见（54%比18%；P < 0.001）。该模型比较有半月板损伤与无半月板损伤（根据基线年龄、性别、体重指数、体力活动和膝关节机械对齐进行调整），优势比为5.7（95%可信区间3.4-9.4）。对于未手术的膝关节，半月板损伤是影像学骨性关节炎发展的一个潜在危险因素。这些结果强调了更好地理解、预防和治疗半月板损伤的必要性。
Although partial meniscectomy is a risk factor for the development of knee osteoarthritis (OA), there is a lack of evidence that meniscal damage that is not treated with surgery would also lead to OA, suggesting that surgery itself may cause joint damage. Furthermore, meniscal damage is common. The aim of this study was to evaluate the association between meniscal damage in knees without surgery and the development of radiographic tibiofemoral OA. We conducted a prospective case–control study nested within the observational Multicenter Osteoarthritis Study, which included a sample of men and women ages 50–79 years at high risk of knee OA who were recruited from the community. Patients who had no baseline radiographic knee OA but in whom tibiofemoral OA developed during the 30-month followup period were cases (n = 121). Control subjects (n = 294) were drawn randomly from the same source population as cases but had no knee OA after 30 months of followup. Individuals whose knees had previously undergone surgery were excluded. Meniscal damage was defined as the presence of any medial or lateral meniscal tearing, maceration, or destruction. Meniscal damage at baseline was more common in case knees than in control knees (54% versus 18%; P < 0.001). The model comparing any meniscal damage with no meniscal damage (adjusted for baseline age, sex, body mass index, physical activity, and mechanical knee alignment) yielded an odds ratio of 5.7 (95% confidence interval 3.4–9.4). In knees without surgery, meniscal damage is a potent risk factor for the development of radiographic OA. These results highlight the need for better understanding, prevention, and treatment of meniscal damage.
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影响因子：
168.9
作者：
Lopez, Alan D.;Mathers, Colin D.;Murray, Christopher J. L.
通讯作者：
Murray, Christopher J. L.
影响因子：
3.8
作者：
Herrlin, Sylvia;Hallander, Maria;Werner, Suzanne
通讯作者：
Werner, Suzanne
影响因子：
2.7
作者：
HEDE, A;LARSEN, E;SANDBERG, H
通讯作者：
SANDBERG, H
影响因子：
--
作者：
Felson, David T.;Niu, Jingbo;Aliabadi, Piran
通讯作者：
Aliabadi, Piran
影响因子：
--
作者：
Hunter, DJ;Zhang, YQ;Felson, DT
通讯作者：
Felson, DT