Multiple tumor types may originate from bone marrow-derived cells
Multiple tumor types may originate from bone marrow-derived cells
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多种肿瘤类型可能源自骨髓源性细胞
DOI：
10.1593/neo.06253
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发表时间：
2006-09-01
期刊：
影响因子：
4.8
通讯作者：
Lu, Yuan
中科院分区：
文献类型：
--
作者：
Liu, Chunfang;Chen, Zhongwei;Lu, Yuan
人们认为，肿瘤起源于其组织特异性干细胞的转化。然而，骨髓来源的细胞(BMDCs)具有意想不到的可塑性，通常存在于其他组织中，也可能是潜在的恶性肿瘤来源。为了研究BMDCs是否在其他肿瘤的来源中起作用，用3-甲基胆蒽处理小鼠的BMDCs，直到实现恶性转化。在此，我们发现转化的BMDCs可以在体内形成多种肿瘤类型，包括上皮性肿瘤、神经肿瘤、肌肉肿瘤、成纤维细胞肿瘤、血管内皮细胞肿瘤和低分化肿瘤。此外，单个转化的BMDC具有自我更新、体外自发分化为多种类型的肿瘤细胞、表达与多能性相关的标志以及在体内形成畸胎瘤的能力。这些数据表明，多潜能癌症干细胞似乎来自转化的骨髓基质细胞。总之，这些发现揭示了BMDCs可能是许多肿瘤类型的来源，甚至是畸胎瘤。此外，多潜能肿瘤干细胞可能来源于恶性转化的骨髓基质细胞。
It was believed that tumors originated from the transformation of their tissue-specific stem cells. However, bone marrow-derived cells (BMDCs), which possess an unexpected degree of plasticity and often reside in other tissues, might also represent a potential source of malignancy. To study whether BMDCs play a role in the source of other tumors, BMDCs from mice were treated with 3-methycholanthrene until malignant transformation was achieved. Here we show that transformed BMDCs could form many tumor types, including epithelial tumors, neural tumors, muscular tumors, tumors of fibroblasts, blood vessel endothelial tumors, and tumors of poor differentiation in vivo. Moreover, a single transformed BMDC has the ability to self-renew, differentiate spontaneously into various types of tumor cells in vitro, express markers associated with multipotency, and form teratoma in vivo. These data suggest that multipotent cancer stem cells seemed to originate from transformed BMDCs. Conclusively, these findings reveal that BMDCs might be a source of many tumor types, even teratoma. In addition, multipotent cancer stem cells might originate from malignant transformed BMDCs.