Distinct features of distant metastasis and lymph node stage in lung adenocarcinoma patients with epidermal growth factor receptor gene mutations
Distinct features of distant metastasis and lymph node stage in lung adenocarcinoma patients with epidermal growth factor receptor gene mutations
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DOI：
10.1016/j.resinv.2013.02.004
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发表时间：
2013-09-01
影响因子：
3.1
通讯作者：
Kojima, Eiji
中科院分区：
文献类型：
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作者：
Enomoto, Yasunori;Takada, Kazuto;Kojima, Eiji
背景资料：表皮生长因子受体（EGFR）突变状态对远处和淋巴结转移的影响尚未完全了解。方法：对95例连续IV期肺腺癌患者进行EGFR突变状态检查，回顾性分析诊断时远处转移的数量和淋巴结转移的临床分期。结果：虽然EGFR突变状态不影响肺、脑或肝中是否存在远处转移，但EGFR突变患者在肺（中位数：85 vs. 4，P=0.01）和脑（11 vs. 3.5，P =0.04）中的转移性病变数量显著更多。另一方面，EGFR突变患者的淋巴结分期显著降低（P
Background: The influence of epidermal growth factor receptor (EGFR) mutation status on distant and lymph node metastasis is not fully understood.Methods: Ninety-five consecutive patients with stage IV lung adenocarcinoma, who had been examined for the EGFR mutation status, were retrospectively analyzed with regard to numbers of distant metastasis and clinical stage of lymph node metastasis at the time of diagnosis.Results: While EGFR mutation status did not influence the presence or absence of distant metastasis in the lung, brain, or liver, patients with EGFR mutations demonstrated a significantly greater number of metastatic lesions in the lung (median: 85 vs. 4, P=0.01) and the brain (11 vs. 3.5, P =0.04). On the other hand, patients with EGFR mutations showed a significantly lower lymph node staging (P