A rapid drug release system with a NIR light-activated molecular switch for dual-modality photothermal/antibiotic treatments of subcutaneous abscesses
A rapid drug release system with a NIR light-activated molecular switch for dual-modality photothermal/antibiotic treatments of subcutaneous abscesses
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DOI：
10.1016/j.jconrel.2014.12.011
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发表时间：
2015-02-10
影响因子：
10.8
通讯作者：
Sung, Hsing-Wen
中科院分区：
文献类型：
--
作者：
Chiang, Wei-Lun;Lin, Tzu-Tsen;Sung, Hsing-Wen
根除皮下细菌感染仍然是一项重大挑战。本研究报告了一种可注射的中空微球（HMs）系统，它可以在近红外（NIR）光的激活下快速产生局部热，并通过其聚合物外壳中的“分子开关”控制抗生素的释放，作为治疗皮下脓肿的一种组合策略。HMs有一个聚（D， l -乳酸-羟基乙酸）（PLGA）的外壳和一个由万古霉素（Van）和聚吡咯纳米粒子（PPy NPs）组成的水核，它们是光热剂。实验结果表明，微hms能有效地保证其包封的Van和PPy NPs在皮下脓肿小鼠注射部位的空间稳定。在没有近红外光照射的情况下，HMs洗脱的药物浓度可以忽略不计，但在近红外光照射下释放的药物浓度要高得多，这表明该系统适合作为光热响应性药物递送系统。光热诱导的热疗和抗生素治疗结合HMs增加了脓肿细菌的细胞毒性，其程度大于单独两种治疗的总和，显示出协同效应。该治疗平台可能会有其他临床应用，特别是局部热疗癌症治疗。(C) 2014 Elsevier B.V.版权所有
Eradicating subcutaneous bacterial infections remains a significant challenge. This work reports an injectable system of hollow microspheres (HMs) that can rapidly produce localized heat activated by near-infrared (NIR) light and control the release of an antibiotic via a "molecular switch" in their polymer shells, as a combination strategy for treating subcutaneous abscesses. The HMs have a shell of poly(D,L-lactic-co-glycolic acid) (PLGA) and an aqueous core that is comprised of vancomycin (Van) and polypyrrole nanoparticles (PPy NPs), which are photothermal agents. Experimental results demonstrate that the micro-HMs ensure efficiently the spatial stabilization of their encapsulated Van and PPy NPs at the injection site in mice with subcutaneous abscesses. Without NIR irradiation, the HMs elute a negligible drug concentration, but release substantially more when exposed to NIR light, suggesting that this system is suitable as a photothermally-responsive drug delivery system. The combination of photothermally-induced hyperthermia and antibiotic therapy with HMs increases cytotoxicity for bacteria in abscesses, to an extent that is greater than the sum of the two treatments alone, demonstrating a synergistic effect. This treatment platform may find other clinical applications, especially for localized hyperthermia-based cancer therapy. (C) 2014 Elsevier B.V. All rights reserved.