Functional Connectivity and Brain Networks in Schizophrenia
Functional Connectivity and Brain Networks in Schizophrenia
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DOI：
10.1523/jneurosci.0333-10.2010
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发表时间：
2010-07-14
影响因子：
5.3
通讯作者：
Bullmore, Edward T.
中科院分区：
文献类型：
--
作者：
Lynall, Mary-Ellen;Bassett, Danielle S.;Bullmore, Edward T.
精神分裂症通常被认为是大规模大脑网络组件之间的连接障碍。我们通过测量15名健康志愿者（14名男性，1名女性）和12名诊断为精神分裂症的人（10名男性，2名女性）在17分钟内在72个大脑区域获得的静息状态fMRI时间序列的功能连接和功能网络拓扑结构来验证这一假设。我们研究了在0.06-0.125 Hz频率区间内功能连接的强度和多样性的组间差异，以及由阈值区域间相关矩阵构建的无向图的一些拓扑性质。在精神分裂症患者中，功能连接的强度显著降低，而功能连接的多样性增加。从拓扑学上讲，功能性大脑网络减少了集群和小世界性，降低了高度枢纽的概率，并增加了精神分裂症患者组的鲁棒性。降低程度和集群是局部显着的内侧顶叶，前运动和扣带回，和右眶额皮质节点的功能网络精神分裂症。功能连接和拓扑指标相互关联，并与行为表现的语言流畅性任务。我们的结论是，精神分裂症患者往往有一个不太强的整合，更多样化的配置文件的大脑功能连接，与一个不太枢纽主导的配置复杂的大脑功能网络。然而，除了这些行为上的不利差异之外，精神分裂症患者组的大脑网络还表现出对随机攻击的更强鲁棒性，这表明精神分裂症连接体可能有好处，如果表达不那么极端的话。
Schizophrenia has often been conceived as a disorder of connectivity between components of large-scale brain networks. We tested this hypothesis by measuring aspects of both functional connectivity and functional network topology derived from resting-state fMRI time series acquired at 72 cerebral regions over 17 min from 15 healthy volunteers (14 male, 1 female) and 12 people diagnosed with schizophrenia (10 male, 2 female). We investigated between-group differences in strength and diversity of functional connectivity in the 0.06-0.125 Hz frequency interval, and some topological properties of undirected graphs constructed from thresholded interregional correlation matrices. In people with schizophrenia, strength of functional connectivity was significantly decreased, whereas diversity of functional connections was increased. Topologically, functional brain networks had reduced clustering and small-worldness, reduced probability of high-degree hubs, and increased robustness in the schizophrenic group. Reduced degree and clustering were locally significant in medial parietal, premotor and cingulate, and right orbitofrontal cortical nodes of functional networks in schizophrenia. Functional connectivity and topological metrics were correlated with each other and with behavioral performance on a verbal fluency task. We conclude that people with schizophrenia tend to have a less strongly integrated, more diverse profile of brain functional connectivity, associated with a less hub-dominated configuration of complex brain functional networks. Alongside these behaviorally disadvantageous differences, however, brain networks in the schizophrenic group also showed a greater robustness to random attack, pointing to a possible benefit of the schizophrenia connectome, if less extremely expressed.