Temporal pole morphology and psychopathology in males with schizophrenia
Temporal pole morphology and psychopathology in males with schizophrenia
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DOI：
10.1016/j.pscychresns.2004.09.002
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发表时间：
2004-12-15
影响因子：
2.3
通讯作者：
Magnotta, V
中科院分区：
文献类型：
--
作者：
Crespo-Facorro, B;Nopoulos, PC;Magnotta, V
边缘系统的功能障碍与精神分裂症的病理生理学有关。颞极（TP）是边缘回路的相关组成部分。功能和结构影像学研究显示，在TP的局限性异常。受试者为30名对照组和30名精神分裂症患者。精确测量TP的皮质表面大小和灰质体积，以探讨精神分裂症患者TP皮质的形态以及TP测量与临床变量的关系。结构测量与临床维度之间的相关性。患病时间。和累积的精神抑制剂暴露量。既没有宏观异常的TP，也没有差异的模式不对称的证明。TP量与精神病性和紊乱性维度得分呈负相关。在精神分裂症患者的TP中没有发现形态学异常。有趣的是，TP体积的减少，高阶多模态关联皮层与紊乱和精神病症状的严重程度相关（C）2004爱思唯尔爱尔兰有限公司保留所有权利。
A dysfunction of the paralimbic system has been implicated in the pathophysiology of schizophrenia. The temporal pole (TP) is a relevant component of the paralimbic circuit. Functional and structural imaging studies have shown circumscribed abnormalities in the TP. Subjects were 30 controls and 30 schizophrenia patients. Cortical surface size and gray matter volume of the TP were accurately measured to explore the morphology of the TP cortex and the relationship of TP measures to clinical variables in patients with schizophrenia. Correlations between structural measures and clinical dimensions. duration of illness. and cumulative neuroleptic exposure were determined. Neither macroscopic abnormalities in the TP nor differences in the pattern of asymmetry were demonstrated. The TP volume was correlated negatively to the psychotic and disorganized dimension scores. No other significant correlations were found. No morphological abnormalities in the TP were found in patients with schizophrenia. Interestingly, a reduction in the TP volume, a higher-order multimodal association cortex was associated with the severity of disorganized and psychotic symptoms (C) 2004 Elsevier Ireland Ltd. All rights reserved.