Mitochondrial DNA polymorphisms are associated with susceptibility and phenotype of systemic lupus erythematosus
Mitochondrial DNA polymorphisms are associated with susceptibility and phenotype of systemic lupus erythematosus
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DOI：
10.1177/0961203308097477
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发表时间：
2009-04-01
期刊：
影响因子：
2.6
通讯作者：
Bengtsson, A. A.
中科院分区：
文献类型：
--
作者：
Jonsen, A.;Yu, X.;Bengtsson, A. A.
本研究的目的是探讨线粒体DNA多态性与系统性红斑狼疮（SLE）的可能关联。来自瑞典隆德大学医院流变学系的一个队列，包括166名无关的SLE患者和190名无关的健康献血者。确诊SLE时的平均年龄为39岁（范围10-83岁），平均随访时间为16年（范围1-44年）。狼疮患者中有87%是女性，对照组由来自同一地理区域的98名女性和92名男性组成，年龄和种族相似。mtDNASNPnt 16189 C与SLE相关（OR = 1.98，95% CI 1.04-3.78，P = 0.05）。此外，SNP nt 13708 A与男性SLE相关（OR = 3.46，95%CI 1.08-11.1，P = 0.04），尽管男性患者数量较少。此外，SNP nt 10398 A与继发性抗磷脂综合征相关（P = 0.017，OR 8.2，95%CI 1.1-63）。总之，在这项研究中，我们首次调查了SLE疾病和线粒体DNA多态性之间的可能联系。总之，这些新的结果表明，线粒体DNA多态性可能与SLE的发展，并可能在SLE发病机制的重要性。Lupus（2009）18，309-312.
The objective of this study was to investigate the possible association between mitochondrial DNA polymorphisms and systemic lupus erythematosus (SLE). A cohort from the Department of Rheumatology, Lund University Hospital, Sweden, consisting of 166 unrelated SLE patients was investigated as well as 190 unrelated healthy blood donors. Mean age at SLE diagnosis was 39 years (range 10-83) and mean follow-up time was 16 years (range 1-44). There were 87% women among the lupus patients, and the control group consisted of 98 women and 92 men from the same geographical area and with a similar age and ethnicity. The mtDNA SNP nt16189C was associated with SLE (OR = 1.98, 95% CI 1.04-3.78, P = 0.05). In addition, SNP nt13708A was associated with SLE in males (OR = 3.46, 95% CI 1.08-11.1, P = 0.04), although the number of male patients was low. Furthermore, SNP nt10398A was associated with secondary anti-phospholipid syndrome (P = 0.017, OR 8.2, 95% CI 1.1-63). In conclusion, in this study, we have for the first time investigated the possible association between SLE disease and mitochondrial DNA polymorphisms. Altogether, these novel results suggest that mtDNA polymorphisms may be associated with development of SLE and may potentially be of importance in SLE pathogenesis. Lupus (2009) 18, 309-312.