Neutrophil-mediated mycobacteriocidal immunity in the lung during Mycobacterium bovis BCG infection in C57BL/6 mice
Neutrophil-mediated mycobacteriocidal immunity in the lung during Mycobacterium bovis BCG infection in C57BL/6 mice
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DOI：
10.1128/iai.70.9.5322-5327.2002
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发表时间：
2002-09-01
影响因子：
3.1
通讯作者：
Boom, WH
中科院分区：
文献类型：
--
作者：
Fulton, SA;Reba, SM;Boom, WH
虽然中性粒细胞已被确定为炎症细胞因子和趋化因子的来源，但对其在肺分枝杆菌感染中的免疫功能知之甚少。在这项研究中，我们在改变中性粒细胞向肺部募集的实验条件下检测了牛分枝杆菌卡介苗在肺部的生长。中性粒细胞的消耗和募集分别与牛分枝杆菌BCG生长的增加和减少有关。因此，中性粒细胞可以增强肺部的杀分枝杆菌免疫。
Although neutrophils have been identified as sources of inflammatory cytokines and chemokines, little is known about their immunologic function during mycobacterial infection in the lungs. In this study, we examined the growth of Mycobacterium bovis BCG in the lungs under experimental conditions that altered neutrophil recruitment to the lungs. Depletion and recruitment of neutrophils was associated with respective increases and decreases in M. bovis BCG growth. Thus, neutrophils may enhance mycobacteriocidal immunity in the lungs.