Glucocorticoids as an adjuvant treatment to intravenous antibiotics for cystic fibrosis pulmonary exacerbations: A UK survey
Glucocorticoids as an adjuvant treatment to intravenous antibiotics for cystic fibrosis pulmonary exacerbations: A UK survey
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DOI：
10.1016/j.jcf.2006.12.009
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发表时间：
2007-07-01
影响因子：
5.2
通讯作者：
Jarad, N. A.
中科院分区：
文献类型：
--
作者：
Hester, K. L. M.;Powell, T.;Jarad, N. A.
口服糖皮质激素广泛用于治疗哮喘和COPD的急性发作。它们在治疗囊性纤维化（CF）恶化中的作用尚未得到证实。我们描述了目前的做法，在英国成人CF医生，口服糖皮质激素作为一种辅助静脉（IV）抗生素治疗CF肺恶化（PEX）。该调查还调查了医生是否认为随机对照试验（RCT）是必要的，以及他们是否愿意让患者参加这样的试验。所有患者均使用皮质类固醇激素和PEX。大多数医生支持需要一个随机对照试验，并愿意招募同意的患者在trial.This调查强调需要一个随机对照试验，将检查辅助皮质类固醇的作用，IV抗生素在CF P EX。(C)2007年欧洲囊性纤维化协会。Elsevier B.V.出版，保留所有权利。
Oral glucocorticoids are widely used to treat exacerbations of asthma and COPD. A role for their use in treating exacerbations in Cystic Fibrosis (CF) is not proven. We describe the current practice, amongst UK adult CF physicians, of oral glucocorticoid use as an adjuvant to intravenous (IV) antibiotic treatment during CF pulmonary exacerbation (P EX). The survey also examined whether physicians thought a randomised controlled trial (RCT) was necessary and their willingness to participate patients in such a trial.Eighty one percent of physicians replied. All of them used corticosteroids with P EX. Most physicians supported the need for a RCT and would be willing to enrol consenting patients in the trial.This survey highlighted the need for a RCT which would examine the role of adjuvant corticosteroids to IV antibiotics in CF P EX. (C) 2007 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.