Perceived psychological stress and serum leptin concentrations in Japanese men
Perceived psychological stress and serum leptin concentrations in Japanese men
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DOI：
10.1038/oby.2006.211
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发表时间：
2006-10-01
期刊：
影响因子：
6.9
通讯作者：
Toyoshima, Hideaki
中科院分区：
文献类型：
--
作者：
Otsuka, Rei;Yatsuya, Hiroshi;Toyoshima, Hideaki
目的：流行病学研究是否受试者具有较高的压力感知水平有较高的leptin concentration.Research方法和程序：在这个横断面研究中，研究人群包括1062名男性工作人员在日本中部的地方政府办公室。1997年分发了自填问卷。通过以下问题评估压力意识：“你生活中压力大吗？参与者被要求从四种可能的回答中选择：“非常多“，”很多“，“普通”，或“很少”。结果：平均（标准差）年龄和BMI分别为250.2（6.4）岁和23.3（2.6）kg/m2。根据压力类别的粗瘦素浓度分别为2.86，3.26，3.32和3.54 ng/mL，根据年龄，BMI，体力活动，饮酒和吸烟习惯，加班，轮班工作，睡眠时间和知己的可用性调整的瘦素浓度分别为2.96，3.24，3.34和3.43 ng/mL，对于“小”，“普通”，“非常多”和“非常多”（单因素协方差分析p = 0.03;线性趋势检验p < 0.01）。显着的协会之间的水平也观察到感知心理压力和工作相关的压力源，变量相关的睡眠，和其他心理variables.Discussion：这项研究表明，受试者谁感知心理压力有高瘦素水平，这提供了流行病学证据表明，心理压力可能有潜在的影响，增加血液中的多效性肽，瘦素水平。
Objective: To examine epidemiologically whether subjects with higher stress perception levels have higher leptin concentrations.Research Methods and Procedures: In this cross-sectional study, the study population comprised 1062 male workers at local government offices in central Japan. Self-administered questionnaires were distributed in 1997. Awareness of stress was assessed by the question: "Do you have much stress in your life?" and participants were asked to select from four possible responses: "very much," "much" "ordinary," or "little." Blood samples were also collected after fasting 12 hours overnight to determine serum leptin concentrations.Results: The mean (standard deviation) age and BMI were 2 50.2 (6.4) years and 23.3 (2.6) kg/m, respectively. Crude leptin concentrations according to stress categories were 2.86, 3.26, 3.32, and 3.54 ng/mL, respectively, and leptin concentrations adjusted for age, BMI, physical activity, drinking and smoking habits, overtime work, shift work, sleep duration, and availability of confidants were 2.96, 3.24, 3.34, and 3.43 ng/mL for "little," "ordinary," "much," and "very much," respectively (p = 0.03 by one-way analysis of covariance; p < 0.01 by test of linear trend). Significant associations were also observed among the level of perceived psychological stress and work-related stressors, variables related to sleep, and other psychological variables.Discussion: This study showed that subjects who perceived psychological stress had high leptin levels, which provides epidemiological evidence that psychological stress may have the potential effect of increasing blood levels of the pleiotropic peptide, leptin.