A General Strategy For One-Step Fabrication Of Biocompatible Microcapsules With Controlled Active Release
A General Strategy For One-Step Fabrication Of Biocompatible Microcapsules With Controlled Active Release
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一步制造具有受控活性释放的生物相容性微胶囊的通用策略
DOI：
10.1016/j.cclet.2019.04.040
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发表时间：
2020
影响因子：
9.1
通讯作者：
David A. Weitz
中科院分区：
文献类型：
--
作者：
Zeyong Sun;Chenjing Yang;Max Eggersdorfer;Jiecheng Cui;Yiwei Li;Mingtan Hai;Dong Chen;David A. Weitz
以可控和可扩展的方式制造生物相容性核-壳微胶囊仍然是一项重要但具有挑战性的任务。在这里，我们开发了一个一步微流控方法的生物相容性微胶囊的高通量生产，利用单一的乳液作为模板，并控制在水/油界面的生物相容性聚合物的沉淀。该方法简便易行，可在核中加载各种油，并通过包覆提高聚合物壳的强度。所得微胶囊具有可控性、可扩展性、生物相容性、高包封率和高负载量的优点。核-壳微胶囊是理想的可编程活性释放的递送载体，并且证明了各种控制释放机制，包括通过剧烈振荡的突释、用于靶向肠释放的pH触发释放和香料在长时间段内的持续释放。我们的技术的实用性为核壳微胶囊的实际应用铺平了道路。(C)2019中国化学会、中国医学科学院药物研究所。
Fabrication of biocompatible core-shell microcapsules in a controllable and scalable manner remains an important but challenging task. Here, we develop a one-step microfluidic approach for the high-throughput production of biocompatible microcapsules, which utilizes single emulsions as templates and controls the precipitation of biocompatible polymer at the water/oil interface. The facile method enables the loading of various oils in the core and the enhancement of polymer shell strength by polyelectrolyte coating. The resulting microcapsules have the advantages of controllability, scalability, biocompatibility, high encapsulation efficiency and high loading capacity. The core-shell microcapsules are ideal delivery vehicles for programmable active release and various controlled release mechanisms are demonstrated, including burst release by vigorous shaking, pH-triggered release for targeted intestinal release and sustained release of perfume over a long period of time. The utility of our technique paves the way for practical applications of core-shell microcapsules. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.