Association of STXBP4/COX11 rs6504950 (G > A) Polymorphism with Breast Cancer Risk: Evidence from 17,960 Cases and 22,713 Controls
Association of STXBP4/COX11 rs6504950 (G > A) Polymorphism with Breast Cancer Risk: Evidence from 17,960 Cases and 22,713 Controls
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DOI：
10.1016/j.arcmed.2012.07.008
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发表时间：
2012-07-01
影响因子：
7.7
通讯作者：
Guan, Xiao-Xiang
中科院分区：
文献类型：
--
作者：
Tang, Lin;Xu, Jing;Guan, Xiao-Xiang
背景和目标。流行病学研究已经调查了STXBP4/COX11 rs6504950（G> A）多态性与乳腺癌易感性之间的关联。然而，结果仍然存在争议。因此，我们对S7XBP4/COX11多态性和乳腺癌风险进行了荟萃分析，以获得最可靠的相关性估计。检索PubMed、Embase和Web of Science数据库。提取粗比值比（OR）和95%置信区间（CI），并汇总以评估STXBP4/COX11 rs6504950（G> A）多态性与乳腺癌风险之间的关联强度。本荟萃分析共纳入4项符合条件的研究，包括17，960例病例和22，713例对照。对照组基因型分布均符合Hardy-Weinberg平衡。我们观察到STXBP4/COX11 rs6504950多态性与乳腺癌风险显著相关，当所有研究合并到荟萃分析中时等位基因对比模型OR = 0.93，95% CI = 0.87-0.99，杂合子共显性模型OR = 0.87，95% CI = 0.83-0.90;优势模型OR = 0.92，95%CI = 0.88-0.96）。这项荟萃分析表明，rs6504950 AA/AG基因型与乳腺癌发生风险显著降低相关。(C)2012年IMSS。爱思唯尔公司出版
Background and Aims. Epidemiological studies have investigated the association between STXBP4/COX11 rs6504950 (G > A) polymorphism and breast cancer susceptibility. However, the results are still controversial. Hence, we conducted a meta-analysis of the S7XBP4/COX11 polymorphism and risk of breast cancer to obtain the most reliable estimate of the association.Methods. PubMed, Embase and Web of Science databases were searched. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were extracted and pooled to assess the strength of the association between STXBP4/COX11 rs6504950 (G > A) polymorphism with breast cancer risk.Results. A total of four eligible studies including 17,960 cases and 22,713 controls based on the search criteria were involved in this meta-analysis. The distributions of genotypes in the controls were all in agreement with Hardy-Weinberg equilibrium. We observed that STXBP4/COX11 rs6504950 polymorphism was significantly correlated with breast cancer risk when all studies were pooled into the meta-analysis (the allele contrast model: OR = 0.93, 95% CI = 0.87-0.99; the heterozygote codominant model: OR = 0.87, 95% CI = 0.83-0.90; the dominant model OR = 0.92, 95% CI = 0.88-0.96).Conclusion. This meta-analysis indicated that the rs6504950 AA/AG genotypes are associated with a significantly decreased risk of breast carcinogenesis. (C) 2012 IMSS. Published by Elsevier Inc.