Maternal inheritance of mitochondrial DNA during backcrossing of two species of mice.
Maternal inheritance of mitochondrial DNA during backcrossing of two species of mice.
复制标题
两种小鼠回交过程中线粒体 DNA 的母系遗传。
作者：
U. Gyllensten;D. Wharton;A. Wilson
限制性内切分析表明，家鼠与小家鼠在6 ~ 8代回交中均表现出严格的母系遗传。据估计，贡献给下一代的父亲线粒体基因组的平均数量不超过母亲线粒体基因组贡献的千分之一。尽管据估计，自从M. spretus和M. domesticus从一个共同的祖先分化以来，它们之间的线粒体dna积累了超过2000个突变差异，但这些线粒体dna中的每一个，无论是在M. spretus还是M. domesticus的核背景下，都允许小鼠以看似正常的生存能力和生育能力发育。
As judged by restriction analysis, mitochondrial DNA shows strictly maternal inheritance during 6-8 generations of backcrossing in both directions between Mus domesticus and Mus spretus. The average number of paternal mitochondrial genomes contributed to the next generation is estimated to be no more than one per thousand maternal mitochondrial genomes contributed. Despite the estimated accumulation of over 2000 mutational differences between M. spretus and M. domesticus mtDNAs since their divergence from a common ancestor, each of these mitochondrial DNAs, whether on a M. spretus or a M. domesticus nuclear background, allows mice to develop with seemingly normal viability and fertility.