SOME METABOLITES OF THE MARINE SPONGES SMENOSPONGIA-AUREA AND SMENOSPONGIA (=POLYFIBROSPONGIA) ECHINA
SOME METABOLITES OF THE MARINE SPONGES SMENOSPONGIA-AUREA AND SMENOSPONGIA (=POLYFIBROSPONGIA) ECHINA
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DOI：
10.1021/jo01296a019
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发表时间：
1980-01-01
影响因子：
3.6
通讯作者：
FAULKNER, DJ
中科院分区：
文献类型：
--
作者：
DJURA, P;STIERLE, DB;FAULKNER, DJ
海绵S. Aurea是5-溴-N，N-二甲基色胺（4）。同一种海绵还含有aureol（6），一种不寻常的倍半甘油-对苯二酚衍生物。S的第二个样本。Aurea含有8-表氯唑萘酚（20）和吲哚（27）。两个S.对棘球蚴进行了检查，发现其中1个样品含有抗菌成分5，6-二溴-N，N-二甲基色胺（3），以及少量苯酚25。通过X射线衍射分析确定了结构aureol（6），而其余化合物的结构则通过光谱数据，特别是13 C NMR光谱和化学互变确定。
The antimicrobial metabolite of the marine sponge S. aurea is 5-bromo-N,N-dimethyltryptamine (4). The same sponge also contained aureol (6), an unusual sesquiterpene-hydroquinone derivative. A 2nd sample of S. aurea contained 8-epichromazonarol (20) and the indole 27. Two samples of S. echina were examined and contained the antimicrobial constituent 5,6-dibromo-N,N-dimethyltryptamine (3), with small amounts of the phenol 25 in 1 sample. The structure aureol (6) was determined by X-ray analysis while those of the remaining compounds were determined from spectroscopic data, particularly 13C NMR spectra, and chemical interconversions.