LIFE-SPAN OF HUMAN LYMPHOCYTE SUBSETS DEFINED BY CD45 ISOFORMS
LIFE-SPAN OF HUMAN LYMPHOCYTE SUBSETS DEFINED BY CD45 ISOFORMS
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DOI：
10.1038/360264a0
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发表时间：
1992-11-19
期刊：
影响因子：
64.8
通讯作者：
BEVERLEY, PCL
中科院分区：
文献类型：
--
作者：
MICHIE, CA;MCLEAN, A;BEVERLEY, PCL
胸腺来源的T淋巴细胞的寿命特别令人感兴趣，因为它们在免疫记忆中起着中心作用。疫苗接种或早期感染的回忆，可能在临床上被证明在抗原免疫后长达50年1，是由长寿细胞保留的，还是由其后代保留的？使用观察，T淋巴细胞表达的亚型的CD45对应于他们的能力，以回应回忆抗原，我们已经调查了寿命的CD45R0（子集包含响应者，或“记忆”细胞）和CD45RA（无反应，或“幼稚”子集）淋巴细胞在一组患者放疗后。在这里，我们报告了不稳定的染色体从CD45R0的快速丢失，但不是CD45RA池。因此，免疫记忆显然存在于分裂速度更快的种群中。两个亚群的不同存活曲线最好通过模型来描述，其中在体内也存在从CD45R0到CD45RA表型的逆转。因此，T细胞中CD45R0的表达可能是可逆的。
THE lifespan of thymic-derived or T lymphocytes is of particular interest because of their central role in immunological memory. Is the recall of a vaccination or early infection, which may be demonstrated clinically up to 50 years after antigen exposure1, retained by a long-lived cell, or by its progeny? Using the observation that T lymphocyte expression of isoforms of CD45 corresponds with their ability to respond to recall antigens, we have investigated the lifespan of both CD45R0 (the subset containing responders, or 'memory' cells) and CD45RA (the unresponsive, or 'naive' subset) lymphocytes in a group of patients after radiotherapy. Here we report rapid loss of unstable chromosomes from the CD45R0 but not the CD45RA pool. Immunological memory therefore apparently resides in a population with a more rapid rate of division. Differing survival curves for the two subsets are best described by a model in which there is also reversion in vivo from the CD45R0 to the CD45RA phenotype. Expression of CD45R0 in T cells may therefore be reversible.