Excitatory effect of propiverine hydrochloride on urethral activity in rats.
Excitatory effect of propiverine hydrochloride on urethral activity in rats.
复制标题
盐酸丙哌维林对大鼠尿道活动的兴奋作用。
DOI：
10.1111/j.1442-2042.2012.02977.x
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
& K. Sugaya.
中科院分区：
文献类型：
--
作者：
K. Kadekawa;S. Nishijima;K. Ashitomi;H. Yamamoto ;& K. Sugaya.
目的：研究抗毒蕈碱药物丙哌维林对大鼠膀胱和尿道的影响。方法：54只雌性大鼠，分别灌胃丙哌维林、抗毒蕈碱药物咪唑那新或蒸馏水，每日1 ~ 2次。2周后，在乌拉坦麻醉下记录膀胱和尿道活动。 在丙哌维林组中，还记录了静脉注射α1-肾上腺素能拮抗剂（哌唑嗪、西洛多辛和萘哌地尔）前后膀胱和尿道活动的变化。此外，泄漏点压力后，电刺激腹壁肌肉测定大鼠阴道扩张从control和propiveverine groups.Results：膀胱内基线压力显着降低，与对照组相比，在丙哌维林和咪唑那新组，而尿道基线压力显着高于丙哌维林组与对照组或咪唑那新组。静脉注射哌唑嗪（一种α1受体拮抗剂）可显著降低丙哌维林组和对照组的基线尿道压力。静脉注射西洛多辛和萘哌地尔（分别为α1A-和α1D-受体拮抗剂）可显著降低丙哌维林组的最大收缩压和尿道基线压。结论：丙哌维林可通过α1A-和α1D-肾上腺素能受体激活近端尿道平滑肌，并通过脊髓运动神经元激活尿道和盆底横纹肌。
Objectives:To investigate the effects of the antimuscarinic agent, propiverine, on the bladder and urethra in rats.Methods:A total of 54 female rats were given propiverine, imidafenacin (an antimuscarinic agent), or distilled water by gavage once or twice daily. After 2 weeks, bladder and urethral activity were recorded under urethane anesthesia. In the propiverine group, the changes of bladder and urethral activity before and after intravenous injection of α1‐adrenergic antagonists (prazosin, silodosin and naftopidil) were also recorded. Furthermore, the leak point pressure after electrical stimulation of abdominal wall muscles was measured in rats with vaginal distension from the control and propiverine groups.Results:Intravesical baseline pressure was significantly lower in the propiverine and imidafenacin groups compared with the control group, whereas the urethral baseline pressure was significantly higher in the propiverine group compared with the control or imidafenacin groups. Intravenous injection of prazosin (an α1‐receptor antagonist) significantly decreased the urethral baseline pressure in both of the propiverine and control groups. Intravenous injection of silodosin and naftopidil (α1A‐ and α1D‐receptor antagonists, respectively) significantly decreased the maximum contraction pressure and the urethral baseline pressure in the propiverine group. The leak point pressure of the propiverine group was significantly higher than that of the control group.Conclusions:An increase of catecholamines after propiverine administration might activate smooth muscle of the proximal urethra via α1A‐ and α1D‐adrenergic receptors, as well as activating urethral and pelvic floor striated muscle via the spinal motoneurons.