Cutaneous cryptococccosis due to Cryptococcus gattii in immunocompetent hosts:: Case report and review
Cutaneous cryptococccosis due to Cryptococcus gattii in immunocompetent hosts:: Case report and review
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DOI：
10.1007/s11046-006-0277-5
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发表时间：
2006-04-01
期刊：
影响因子：
5.5
通讯作者：
Goldani, LZ
中科院分区：
文献类型：
--
作者：
Dora, JM;Kelbert, S;Goldani, LZ
在免疫功能正常的患者中，由格特隐球菌引起的皮肤隐球菌病是一种罕见的疾病表现，并且可能是播散性隐球菌病的首发表现之一。我们报告了一例由格特隐球菌引起的播散性隐球菌病，在免疫功能正常的患者中表现为皮肤病变。在我们的报告之前，文献中仅报道了免疫功能正常患者中格特隐球菌皮肤受累的五例病例。格特隐球菌感染的危险因素包括接触热带和亚热带地区的桉树水库。大多数患者的皮肤受累相当于播散性隐球菌病，通常影响面部和颈部，具有不同的形态，包括丘疹、脓疱、斑块、溃疡、皮下肿块、蜂窝织炎或痤疮样病变。由于这种感染的严重性及其所代表的危及生命的情况，临床医生必须意识到皮肤受累可能是由格特隐球菌引起的播散性隐球菌病的首要表现之一，尤其是生活在流行地区和来自流行地区的患者。
Cutaneous cryptococcosis caused by C. gattii, in immunocompent patients is a rare manifestation of disease, and may be one of the first manifestations of disseminated cryptococcosis. We report a case of disseminated cryptococcosis caused by Cryptococcus gattii presenting as cutaneous lesions in an immunocompetent patient. Previously to our report, only five cases of cutaneous involvement by Cryptococcus gattii in immunocompetent patients have been reported in the literature. Risk factors for C. gattii infection included exposure to the eucalypt reservoirs in tropical and subtropical areas. Skin involvement corresponded to the disseminated form of cryptococcosis in the majority of patients, and commonly affected the face and neck with different morphologies including papules, pustules, plaques, ulcers, subcutaneous masses, cellulitis or acneiform lesions. Due to the severity of this infection and the life threatening condition that it represents, clinicians must be aware that cutaneous involvement may be one of the first manifestations of disseminated cryptococcosis caused by C. gattii especially in patients living and coming from endemic areas.