Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community: the Hisayama Study
Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community: the Hisayama Study
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DOI：
10.1111/j.1600-0447.2010.01587.x
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发表时间：
2010-10-01
影响因子：
6.7
通讯作者：
Kiyohara, Y.
中科院分区：
文献类型：
--
作者：
Sekita, A.;Ninomiya, T.;Kiyohara, Y.
目的：研究日本普通人群中阿尔茨海默病（AD）和血管性痴呆（VD）患病率的长期趋势。方法：分别于1985年、1992年、1998年和2005年对日本某社区年龄为bb0 = 65岁的居民进行了4次横断面调查。结果：经年龄和性别调整后的全因痴呆患病率随时间显著增高（1985年为6.0%，1992年为4.4%，1998年为5.3%，2005年为8.3%，趋势P = 0.002）。AD也有类似的趋势（分别为1.1%、1.3%、2.3%和3.8%,P < 0.001），而VD和其他/未分类痴呆的年龄和性别调整患病率呈j型模式（VD分别为2.3%、1.5%、1.5%和2.5%，P为趋势= 0.82；其他/未分类痴呆为2.6%、1.7%、1.5%和2.0%，P为趋势= 0.26）。从1985年到2005年，在75岁及以上的受试者中，AD的患病率可能随着时间的推移而增加。VD患病率与AD患病率之比随着时间的推移而下降（1985年为2.1,1992年为1.2,1998年为0.7,2005年为0.7）。结论：我们的研究结果表明，在过去二十年中，日本普通人群中全因痴呆和AD的患病率显著增加。
Objective:To examine secular trends in the prevalence of Alzheimer's disease (AD) and vascular dementia (VD) in a general Japanese population.Method:Four cross-sectional examinations were conducted among residents of a Japanese community aged >= 65 in 1985, 1992, 1998 and 2005.Results:The age- and sex-adjusted prevalence of all-cause dementia significantly increased with time (6.0% in 1985, 4.4% in 1992, 5.3% in 1998 and 8.3% in 2005; P for trend = 0.002). A similar trend was observed for AD (1.1%, 1.3%, 2.3% and 3.8% respectively; P for trend < 0.001), while the age- and sex-adjusted prevalence of VD and other/unclassified dementia showed J-shaped patterns (for VD: 2.3%, 1.5%, 1.5% and 2.5%, respectively, P for trend = 0.82; for other/unclassified dementia: 2.6%, 1.7%, 1.5% and 2.0%, P for trend = 0.26). The prevalence of AD was likely to increase with time from 1985 to 2005 among subjects aged 75 or older. The ratio of the prevalence of VD to that of AD decreased with time (2.1 in 1985, 1.2 in 1992, 0.7 in 1998 and 0.7 in 2005).Conclusion:Our findings suggest that the prevalence of all-cause dementia and AD significantly increased over the past two decades in the general Japanese population.