A Cluster-Randomized Trial to Assess the Efficacy of Targeting Trachoma Treatment to Children
A Cluster-Randomized Trial to Assess the Efficacy of Targeting Trachoma Treatment to Children
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DOI：
10.1093/cid/ciw810
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发表时间：
2017-03-15
影响因子：
11.8
通讯作者：
Lietman, Thomas M.
中科院分区：
文献类型：
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作者：
Amza, Abdou;Kadri, Boubacar;Lietman, Thomas M.
背景世界卫生组织建议每年对整个沙眼流行社区进行治疗，尽管儿童通常负荷更高，持续时间更长，感染的可能性更大。尼日尔Matameye的48个社区被随机分为两组，一组是整个社区每年口服阿奇霉素治疗，另一组是仅对0-12岁儿童每两年治疗一次。通过聚合酶链反应监测儿童和成人的眼部衣原体感染。在每年治疗组中，儿童感染的患病率从基线时的21.2%（95%置信区间[CI]，15.2%-28.0%）降至36个月时的5.8%（95% CI，3.2%-9.0%）（P
Background. The World Health Organization recommends annual treatment of entire trachoma-endemic communities, although children typically have a higher load, longer duration, and greater likelihood of infection.Methods. Forty-eight communities in Matameye, Niger, were randomized to annual oral azithromycin treatment of the entire community or biannual treatment of children aged 0-12 years only. Both children and adults were monitored for ocular chlamydial infection by polymerase chain reaction.Results. The prevalence of childhood infection was reduced in the annually treated arm from 21.2% (95% confidence interval [CI], 15.2%-28.0%) at baseline to 5.8% (95% CI, 3.2%-9.0%) at 36 months (P