Connexins: a myriad of functions extending beyond assembly of gap junction channels.
Connexins: a myriad of functions extending beyond assembly of gap junction channels.
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DOI：
10.1186/1478-811x-7-4
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发表时间：
2009-03-12
期刊：
影响因子：
--
通讯作者：
Talhouk RS
中科院分区：
文献类型：
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作者：
Dbouk HA;Mroue RM;El-Sabban ME;Talhouk RS
连接蛋白是跨膜蛋白的一个大家族，它允许细胞间的通讯以及离子和小信号分子在细胞间的转移。最近的研究揭示了复杂的翻译和翻译后机制，调节连接蛋白的合成，成熟，膜转运和降解，进而调节间隙连接细胞间通讯。随着越来越多的连接蛋白相互作用蛋白，包括细胞骨架元件，连接蛋白和酶，间隙连接现在被认为不仅是相邻细胞之间的通道，而且是调节细胞功能和转化的信号复合物。连接蛋白也已被证明形成功能性半通道，并具有完全独立于通道功能的作用，其中它们通过大多数未定义的机制对细胞的增殖和生死的其他方面发挥作用。本文综述了连接蛋白及其相互作用蛋白的最新研究进展，并介绍了连接蛋白在疾病和肿瘤发生中的作用。
Connexins constitute a large family of trans-membrane proteins that allow intercellular communication and the transfer of ions and small signaling molecules between cells. Recent studies have revealed complex translational and post-translational mechanisms that regulate connexin synthesis, maturation, membrane transport and degradation that in turn modulate gap junction intercellular communication. With the growing myriad of connexin interacting proteins, including cytoskeletal elements, junctional proteins, and enzymes, gap junctions are now perceived, not only as channels between neighboring cells, but as signaling complexes that regulate cell function and transformation. Connexins have also been shown to form functional hemichannels and have roles altogether independent of channel functions, where they exert their effects on proliferation and other aspects of life and death of the cell through mostly-undefined mechanisms. This review provides an updated overview of current knowledge of connexins and their interacting proteins, and it describes connexin modulation in disease and tumorigenesis.