Electronic origin of antimicrobial activity owing to surface effect
Electronic origin of antimicrobial activity owing to surface effect
复制标题
由于表面效应而产生的抗菌活性的电子起源
DOI：
10.1038/s41598-018-37645-w
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发表时间：
2019
影响因子：
4.6
通讯作者：
Mabuchi Mamoru
中科院分区：
文献类型：
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作者：
Miyazawa Naoki;Sakakibara Susumu;Hakamada Masataka;Mabuchi Mamoru
纳米材料作为抗菌材料具有广阔的应用前景。然而，由于表面效应的抗菌机制，其中的有害物质，如金属离子和活性氧物种的排放是不需要的，仍然知之甚少。在深入了解抗菌机理的基础上，弄清其物理性质与抗菌活性之间的关系，对抗菌剂的安全、有效应用具有重要意义。在这里，我们表明，功函数是代表的表面效应，导致抗菌活性，这源于表面的电子状态。我们研究了纳米多孔Au-Pt和Au在没有Ag离子发射的情况下的抗菌活性和功函数，发现它们之间存在正相关性。此外，我们进行了第一性原理计算和分子动力学模拟来分析Au表面和细胞壁的电子状态。这说明正相关是由于Au表面的特殊电子态，即电子溢出现象。我们的发现将有助于从物理学角度推进对生物现象的理解。
Nanomaterials have displayed promising potential as antimicrobial materials. However, the antimicrobial mechanism owing to surface effects, where the emission of harmful substances such as metallic ions and reactive oxygen species is not required, is still poorly understood. It is important to figure out relationship between the physical properties and antimicrobial activity based on deep understanding of antimicrobial mechanism for their safe and effective applications. Here, we show that the work function is representative of the surface effect leading to antimicrobial activity, which originates from the electronic states of the surface. We investigated the antimicrobial activity and the work function of nanoporous Au-Pt and Au without the emission of Ag ion, and found that there was a positive correlation between them. In addition, we performed a first-principles calculation and molecular dynamics simulation to analyze the electronic states of the Au surface and the cell wall. These demonstrated that positive correlation was owing to peculiar electronic states at the Au surface, namely, the spilling out phenomenon of electrons. Our finding will contribute to advance the understanding of biological phenomena from a physical view.