Aging and restriction of dietary calories increases insulin receptor mRNA, and aging increases glucocorticoid receptor mRNA in the liver of female C3B10RF1 mice.
Aging and restriction of dietary calories increases insulin receptor mRNA, and aging increases glucocorticoid receptor mRNA in the liver of female C3B10RF1 mice.
复制标题
衰老和饮食热量限制会增加雌性 C3B10RF1 小鼠肝脏中胰岛素受体 mRNA 的含量，而衰老会增加肝脏中糖皮质激素受体 mRNA 的含量。
DOI：
10.1093/geronj/46.6.b233
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Mote,PL
中科院分区：
文献类型：
--
作者：
Spindler,SR;Grizzle,JM;Walford,RL;Mote,PL
我们研究了年龄和饮食热量减少20%或52%（热量限制）对许多转录因子和信号转导蛋白mRNA表达的影响，研究对象是4、16和30个月大的长寿c3B10RF雌性小鼠。在所有年龄组中，52%的热量限制使最大寿命延长了约33%，使胰岛素受体mRNA的水平比自由喂养的动物高15%至25%。衰老使各饮食组胰岛素受体mRNA和糖皮质激素受体mRNA升高。在其他三个品系的雄性小鼠中没有观察到糖皮质激素受体mRNA的类似增加，这表明这种变化是性别或品系特异性的，而不是衰老的一般特征。这些变化似乎是具体的。热量限制和年龄对胰岛素样生长因子- 1、RNA聚合酶II延长因子S-II、转录因子SPL、CCAAT和增强子结合蛋白或原癌基因c-jun的mRNA水平均无影响。
We investigated the influence of age and a 20% or 52% reduction in dietary calories (caloric restriction) on expression of mRNA for a number of transcription factors and signal-transducing proteins using4,16, and 30-monthold female mice of the long-lived c3B10RF, strain. In all age groups, 52% caloric restriction, which extends maximum life span by approximately 33%, increased insulin receptor mRNA by 15% to 25% over the levels in animals fed ad libitum. Aging increased insulin receptor mRNA and glucocorticoid receptor mRNA in all dietary groups. A similar increase in glucocorticoid receptor mRNA was not observed for male mice of three other strains, suggesting the change is sex-or strain-specific and not a general feature of aging. These changes appear to be specific. Neither caloric restriction nor age had an effect on the level of mRNA for insulin-like growth factor-I, RNA polymerase II elongation-factor S-II, or transcription factors SPL, CCAAT and enhancer binding protein, or proto-oncogene c-jun.