Comparative transcriptome analysis reveals that the extracellular matrix receptor interaction contributes to the venous metastases of hepatocellular carcinoma
Comparative transcriptome analysis reveals that the extracellular matrix receptor interaction contributes to the venous metastases of hepatocellular carcinoma
复制标题
比较转录组分析揭示细胞外基质受体相互作用导致肝细胞癌静脉转移
DOI：
10.1016/j.cancergen.2015.06.002
复制
发表时间：
2015-10-01
期刊：
影响因子：
1.9
通讯作者：
Liu, Yun
中科院分区：
文献类型：
--
作者：
Zhang, Hong;Ye, Junyi;Liu, Yun
肝细胞癌（HCC）是世界上最常见的肝癌类型。门静脉癌栓（PVTT）是肝癌最严重的并发症之一，与肝癌患者的预后密切相关。然而，PVTT发展的详细机制仍有待探索。在这项研究中，我们提出了一个大规模的转录组分析，通过RNA测序，11例患者诊断为HOC与PVTT。HOC和PVTT之间的基因表达异常提示细胞外基质受体相互作用与HOC静脉转移有关。在所有复发性选择性剪接事件中，我们鉴定了RPS 24的外显子6跳跃，这可能是癌症驱动因素。我们还鉴定了HOC与其相应PVTT样品之间的五种常见融合基因，包括ARID 1A-GPATCH 3、MDM 1-NUP 107、PTGES 3-RARG、PRLR-TERT和C9 orf 3-TMC 1。所有这些发现拓宽了我们对PVTT发展的认识，也可能有助于HOC伴PVTT患者的诊断和治疗。
Hepatocellular carcinoma (HCC) is the most common type of liver cancer in the world. Portal vein tumor thrombus (PVTT) is one of the most serious complications of HCC and is strongly correlated with a poor prognosis for HCC patients. However, the detailed mechanism of PVTT development remains to be explored. In this study, we present a large-scale transcriptome analysis, by RNA sequencing, of 11 patients diagnosed with HOC with PVTT. The dysregulated genes between HOC and PVTT suggested that the extracellular matrix receptor interaction was correlated with the venous metastases of HOC. Among all of the recurrent alternative splicing events, we identified exon 6 skipping of RPS24, which is likely to be a cancer driver. We also identified five common fusion genes between HOC and its corresponding PVTT samples, including ARID1A-GPATCH3, MDM1-NUP107, PTGES3-RARG, PRLR-TERT, and C9orf3-TMC1. All of these findings broaden our knowledge of PVTT development and may also contribute to the diagnosis and treatment of HOC patients with PVTT.