A Genome-wide Association Study of Periodontitis in a Japanese Population
A Genome-wide Association Study of Periodontitis in a Japanese Population
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DOI：
10.1177/0022034515570315
复制
发表时间：
2015-02
影响因子：
7.6
通讯作者：
Shintaro Shimizu;Y. Momozawa;A. Takahashi;T. Nagasawa;K. Ashikawa;Y. Terada;Y. Izumi;H. Kobayashi;M. Tsuji;M. Kubo;Y. Furuichi
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文献类型：
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作者：
Shintaro Shimizu;Y. Momozawa;A. Takahashi;T. Nagasawa;K. Ashikawa;Y. Terada;Y. Izumi;H. Kobayashi;M. Tsuji;M. Kubo;Y. Furuichi
牙周炎是一种多因素疾病，其中涉及细菌，生活方式和遗传因素。虽然以前的遗传关联研究确定了欧洲人群中牙周炎的易感基因，但亚洲人群的信息很少。在这里，我们进行了一项全基因组关联研究和一项复制研究，包括2，760名日本牙周炎患者和15，158名日本对照。尽管单核苷酸多态性超过了严格的全基因组显著性阈值，（P < 5 × 10−8），我们发现了2个牙周炎的提示位点：KCNQ 5位于染色体6 q13（rs 9446777，P = 4.83 × 10−6，比值比= 0.82），GPR 141-NME 8位于染色体7p14.1（rs 2392510，P = 4.17 × 10−6，比值比= 0.87）。分层分析表明，GPR 141-NME 8基因座对有吸烟史的日本人泛发性牙周炎的易感性有很强的遗传效应。总之，这项研究确定了2个提示位点的牙周炎在日本人口。这项研究有助于进一步了解牙周炎易感性增强的遗传因素。
Periodontitis is a multifactorial disease in which bacterial, lifestyle, and genetic factors are involved. Although previous genetic association studies identified several susceptibility genes for periodontitis in European populations, there is little information for Asian populations. Here, we conducted a genome-wide association study and a replication study consisting of 2,760 Japanese periodontitis patients and 15,158 Japanese controls. Although single-nucleotide polymorphisms that surpassed a stringent genome-wide significance threshold (P < 5 × 10−8) were not identified, we found 2 suggestive loci for periodontitis: KCNQ5 on chromosome 6q13 (rs9446777, P = 4.83 × 10−6, odds ratio = 0.82) and GPR141-NME8 at chromosome 7p14.1 (rs2392510, P = 4.17 × 10−6, odds ratio = 0.87). A stratified analysis indicated that the GPR141-NME8 locus had a strong genetic effect on the susceptibility to generalized periodontitis in Japanese individuals with a history of smoking. In conclusion, this study identified 2 suggestive loci for periodontitis in a Japanese population. This study should contribute to a further understanding of genetic factors for enhanced susceptibility to periodontitis.