Frequency of familial hypercholesterolemia in patients with early-onset coronary artery disease admitted to a coronary care unit
Frequency of familial hypercholesterolemia in patients with early-onset coronary artery disease admitted to a coronary care unit
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DOI：
10.1016/j.jacl.2015.07.005
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发表时间：
2015-10-01
影响因子：
4.4
通讯作者：
Watts, Gerald F.
中科院分区：
文献类型：
--
作者：
Pang, Jing;Poulter, Elissa B.;Watts, Gerald F.
背景：家族性高胆固醇血症（FH）是早期冠状动脉疾病（CAD）最常见的显性遗传原因。然而，在医院环境中，患有早期CAD的患者中FH的诊断未得到充分认识，这也意味着错过了筛查其亲密家庭成员和实施初级预防的机会。目的：调查早发性冠心病患者在冠心病监护病房（CCU）中FH的点患病率。方法：根据改进的荷兰脂质临床网络标准，在CCU环境中调查FH的患病率以及相关CAD危险因素的谱。收集175例冠心病发病年龄5.0 mmol/L的冠心病患者的资料。糖尿病、高血压、肥胖和吸烟在有和没有fr的患者中同样普遍。结论：FH在CCU中有早发性CAD病史的患者中相对常见。应尽一切努力在这些患者中检测FH，并开始对可用的家庭成员进行级联检测，以防止那些可能不知道自己也患有CAD的人发展为CAD。(C) 2015年全国血脂协会。版权所有。
BACKGROUND: Familial hypercholesterolemia (FH) is the most common dominantly inherited cause of premature coronary artery disease (CAD). However, the diagnosis of FH in patients who have premature CAD in hospital settings is under-recognized, this also represents a missed opportunity for screening their close family members and implementing primary prevention.OBJECTIVE: To investigate the point prevalence of FH in a coronary care unit (CCU) among patients with early-onset CAD.METHODS: The prevalence of FH, based on modified phenotypic Dutch Lipid Clinic Network Criteria, and the spectrum of associated CAD risk factors, were investigated in a CCU setting. Data were collected on 175 coronary care patients with onset of CAD at age 5.0 mmol/L. Diabetes, hypertension, obesity, and smoking were common and equally prevalent in patients with and without FR.CONCLUSIONS: FH is relatively frequent among patients with a history of early-onset CAD in the CCU. Every effort should be made to detect FH in these patients and to initiate cascade testing of available family members to prevent the development of CAD in those who may be unaware that they also have the condition. (C) 2015 National Lipid Association. All rights reserved.