Extended-wear lenses, biofilm, and bacterial adhesion.
Extended-wear lenses, biofilm, and bacterial adhesion.
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长期佩戴镜片、生物膜和细菌粘附。
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
A. Gristina
中科院分区：
文献类型：
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作者：
M. Slusher;Q. Myrvik;J. Lewis;A. Gristina
虽然与细菌粘附生物材料有关的医学科学知识在大多数医学领域已成为一个快速发展的领域，但其在眼科感染中的重要性尚未得到强调。配戴隐形眼镜患者角膜细菌性溃疡已成为一个普遍存在的问题。隐形眼镜本身作为细菌定植的合适基质和受损上皮细胞的后续接种源的指定是角膜溃疡形成病理生理学中的重要因素。我们利用细胞化学、扫描和透射电子显微镜技术在体外证明了多糖（生物膜）介导的两种眼部病原体（铜绿假单胞菌和表皮葡萄球菌）在典型的长时间佩戴隐形眼镜表面的粘附。这种生物材料和细菌有机体之间的相互作用，为繁殖和接种提供了有利的自我保护环境，是以前被忽视的与亲水（软）隐形眼镜相关的角膜溃疡机制的重要领域。
While medical scientific knowledge pertaining to bacterial adhesion to biomaterials has become a rapidly growing field in most areas of medicine, its significance in ophthalmic infections has not been emphasized. Corneal bacterial ulceration in patients wearing extended-wear contact lenses has become a problem of epidemic proportions. The designation of the contact lens itself as a suitable substratum for bacterial colonization and as a source of subsequent inoculum to compromised epithelial cells are important factors in the pathophysiology of corneal ulcer formation. We demonstrate polysaccharide- (biofilm-)mediated adhesion to two ophthalmic pathogens (Pseudomonas aeruginosa and Staphylococcus epidermidis) to the surface of a typical extended-wear contact lens in vitro using cytochemistry and scanning and transmission electron microscopic techniques. This interaction between the biomaterial and bacterial organisms, which represents a favorable self-protective environment for propagation and inoculation, is a previously overlooked area of importance in the mechanism of corneal ulceration associated with hydrophilic (soft) contact lenses.
与长期佩戴软性隐形眼镜相关的角膜溃疡。
影响因子：
4.2
作者：
Weissman,BA;Mondino,BJ;Pettit,TH;Hofbauer,JD
通讯作者：
Hofbauer,JD