All Talk, No Assembly: Voltage-Gated Calcium Channels Do Not Mediate Active Zone Formation.

All Talk, No Assembly: Voltage-Gated Calcium Channels Do Not Mediate Active Zone Formation.
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只讨论,不组装:电压门控钙通道不介导活性区的形成。

DOI:
10.1016/j.neuron.2020.07.028
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发表时间:
2020
期刊:
影响因子:
16.2
通讯作者:
Kurshan,PeriT
Kurshan,PeriT
中科院分区:
医学1区
文献类型:
--
作者:
Frankel,ElisaB;Kurshan,PeriT

文献摘要

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突触是如何组装的仍不清楚。在这一期的《神经元》中,赫尔德等人(Held et al.)(2020)证明Cav2型电压门控钙通道不介导突触前组装。此外,通道相关蛋白α2δ独立定位,表明这种辅助蛋白具有其他功能。
How synapses assemble remains unknown. In this issue ofNeuron, Held et al. (2020) demonstrate that Cav2-type voltage-gated calcium channels do not mediate presynaptic assembly. Moreover, the channel-associated protein α2δ localizes independently, suggesting additional functions for this auxiliary protein.