Future directions and treatment strategies for head and neck squamous cell carcinomas.
Future directions and treatment strategies for head and neck squamous cell carcinomas.
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DOI：
10.1016/j.trsl.2012.02.002
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发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Wells SI
中科院分区：
文献类型：
--
作者：
Wise-Draper TM;Draper DJ;Gutkind JS;Molinolo AA;Wikenheiser-Brokamp KA;Wells SI
头颈癌是一种毁灭性的疾病，困扰着世界各地的许多人。常规疗法仅在有限的亚组中是成功的，并且通常使患者具有毁容和对正常生理功能的长期持续的不利影响。该领域迫切需要新的疗法。溶瘤病毒以及靶向治疗在其他恶性肿瘤中已经显示出一些成功，并且对于治疗头颈部癌症是有吸引力的。最近，它已被证明，一个子集的头颈部癌症是人乳头瘤病毒（HPV）阳性，这一子集的癌症是生物学上不同的，更敏感的放化疗治疗，虽然潜在的机制尚不清楚。然而，耐药性仍然是一个普遍的问题。治疗反应的一种候选介体是人DEK原癌基因，其对于靶向HPV阳性和阴性肿瘤都是有意义的。DEK在许多肿瘤中上调，包括头颈癌，无论其HPV状态如何。培养物中肿瘤细胞中DEK的耗尽导致对遗传毒性剂的敏感性，特别是在快速增殖的细胞中。这表明具有高DEK蛋白表达的肿瘤可能与对致染色体断裂疗法的不良临床反应相关。靶向分子如DEK与新的和/或常规疗法组合，有望成为头颈癌的新的未来疗法。
Head and neck cancer is a devastating disease that afflicts many individuals worldwide. Conventional therapies are successful in only a limited subgroup and often leave the patient with disfigurement and long lasting adverse effects on normal physiological functions. The field is in dire need of new therapies. Oncolytic viral as well as targeted therapies have shown some success in other malignancies and are attractive for the treatment of head and neck cancer. Recently, it has been shown that a subset of head and neck cancers is human papillomavirus (HPV) positive and that this subset of cancers is biologically distinct and more sensitive to chemoradiation therapies although the underlying mechanism is unclear. However, chemoresistance remains a general problem. One candidate mediator of therapeutic response, which is of interest for the targeting of both HPV-positive and -negative tumors is the human DEK proto-oncogene. DEK is upregulated in numerous tumors including head and neck cancers regardless of their HPV status. Depletion of DEK in tumor cells in culture results in sensitivity to genotoxic agents, particularly in rapidly proliferating cells. This suggests that tumors with high DEK protein expression may be correlated with poor clinical response to clastogenic therapies. Targeting molecules such as DEK in combination with new and/or conventional therapies, holds promise for novel future therapeutics for head and neck cancer.
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影响因子：
8.8
作者：
del Campo, J. M.;Hitt, R.;Sebastian, P.;Carracedo, C.;Lokanatha, D.;Bourhis, J.;Temam, S.;Cupissol, D.;De Raucourt, D.;Maroudias, N.;Nutting, C. M.;Compton, N.;Midwinter, D.;Downie, L.;Biswas-Baldwin, N.;El-Hariry, I.;Harrington, K. J.
通讯作者：
Harrington, K. J.
影响因子：
3.3
作者：
Czeminski, Rakefet;Amornphimoltham, Panomwat;Gutkind, J. Silvio
通讯作者：
Gutkind, J. Silvio
影响因子：
50.5
作者：
Chung, C. H.;Aulino, J.;Murphy, B. A.
通讯作者：
Murphy, B. A.
影响因子：
4.3
作者：
Carro, Maria Stella;Spiga, Fabio Mario;Muller, Heiko
通讯作者：
Muller, Heiko
影响因子：
11.5
作者：
Harrington, Kevin J.;Hingorani, Mohan;Nutting, Christopher M.
通讯作者：
Nutting, Christopher M.