UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue
UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue
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DOI：
10.1006/bbrc.1997.6740
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发表时间：
1997-06-09
影响因子：
3.1
通讯作者：
Lowell, BB
中科院分区：
文献类型：
--
作者：
VidalPuig, A;Solanes, G;Lowell, BB
解偶联蛋白(UCP)是线粒体膜内的转运蛋白，它能驱散质子梯度，以热的形式释放储存的能量。UCP1仅在棕色脂肪细胞中表达，而UCP2广泛表达。我们现在报道第三个解偶联蛋白同源物的分子克隆，命名为UCP3。在氨基酸水平上，hUCP3与hUCP2同源性为71%，与hUCP1同源性为57%。UCP3不同于UCP1和UCP2，它在人类骨骼肌、啮齿类动物棕色脂肪组织和骨骼肌中大量优先表达。由于骨骼肌和棕色脂肪组织分别被认为是人类和啮齿动物调节能量消耗的重要部位，UCP3可能是适应性产热的重要中介。由于UCP3在人类心脏和其他重要器官中的表达水平最低，因此它是旨在增加产热的抗肥胖药物开发的一个有前途的靶点。(C)1997年学术出版社。
Uncoupling proteins (UCPs) are inner mitochondrial membrane transporters which dissipate the proton gradient, releasing stored energy as heat. UCP1 is expressed exclusively in brown adipocytes while UCP2 is expressed widely. We now report the molecular cloning of a third uncoupling protein homologue, designated UCP3. At the amino acid level, hUCP3 is 71% identical to hUCP2 and 57% identical to hUCP1. UCP3 is distinguished from UCP1 and UCP2 by its abundant and preferential expression in skeletal muscle in humans, and brown adipose tissue and skeletal muscle in rodents. Since skeletal muscle and brown adipose tissue are believed to be important sites for regulated energy expenditure in humans and rodents, respectively, UCP3 may be an important mediator of adaptive thermogenesis. Since UCP3 is minimally expressed in human heart and other critical organs, it is a promising target for anti-obesity drug development aimed at increasing thermogenesis. (C) 1997 Academic Press.