Associations of components of adult height with coronary heart disease in postmenopausal women: the British women's heart and health study
Associations of components of adult height with coronary heart disease in postmenopausal women: the British women's heart and health study
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DOI：
10.1136/hrt.2003.019950
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发表时间：
2004-07-01
期刊：
影响因子：
5.7
通讯作者：
Ebrahim, S
中科院分区：
文献类型：
--
作者：
Lawlor, DA;Taylor, M;Ebrahim, S
目的：探讨绝经后女性成年身高构成因素与冠心病的关系。方法：对英国23个城镇随机抽取的4286名女性进行横断面分析。结果：在年龄调整分析中，身高、腿长和躯干长度均与冠心病相关。经吸烟调整后，躯干长度与CHD之间的关联减弱至零。腿长与冠心病的关系与吸烟、儿童和成年时的社会经济地位、出生体重和其他潜在的混杂因素无关。胰岛素抵抗似乎不是腿长和冠心病之间联系的重要中介因素。在充分调整所有潜在的混杂因素后，腿长增加1 SD(4.3 cm)患冠心病的优势比(95%可信区间)为0.84(0.77~0.93)，腿干比增加1 SD(0.05)患冠心病的优势比(OR)为0.85(0.79~0.95)。结论：腿长与CHD的特异性关联提示，影响骨骼生长的早期环境暴露也会影响以后的CHD风险。
Objective: To assess the associations between components of adult height and coronary heart disease (CHD) in postmenopausal women.Methods: Cross sectional analysis of 4286 women randomly selected from 23 British towns. The association of components of adult height with prevalent CHD (n = 694) were assessed.Results: Shorter stature, shorter leg length, and trunk length were all associated with CHD in age adjusted analyses. The association between trunk length and CHD was attenuated to the null with adjustment for smoking. The leg length - CHD association was independent of smoking, socioeconomic position in childhood and adulthood, birth weight, and other potential confounders. Insulin resistance did not appear to be an important mediating factor in the association between leg length and CHD. After full adjustment for all potential confounding factors the odds ratio (95% confidence interval) of CHD for a 1 SD (4.3 cm) increase in leg length was 0.84 (0.77 to 0.93) and the odds ratio for a 1 SD (0.05) increase in the leg to trunk ratio was 0.85 (0.79 to 0.95).Conclusions: The specific association between leg length and CHD suggests that early life environmental exposures that influence skeletal growth also influence CHD risk in later life.