Integrated exposure and risk characterization of bisphenol-A in Europe
Integrated exposure and risk characterization of bisphenol-A in Europe
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DOI：
10.1016/j.fct.2016.10.017
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发表时间：
2016-12-01
影响因子：
4.3
通讯作者：
Gotti, Alberto
中科院分区：
文献类型：
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作者：
Sarigiannis, Dimosthenis A.;Karakitsios, Spyros P.;Gotti, Alberto
目前的研究旨在通过一个集成的暴露建模框架来支持双酚a （BPA）的综合风险特征，该框架包括远场和近场暴露建模以及动态寿命PBTK模型。对欧洲双酚a食品残留数据和人体生物监测（HBM）进行暴露分析。后者通过先进的暴露重建模型框架进一步同化，以估计相应的BPA及其代谢物的外部和内部全身剂量。通过模拟母体-胎儿毒性动力学相互作用，特别关注在关键发育阶段（如妊娠期）暴露于双酚a的评估。我们的研究结果表明，目前欧洲的暴露水平低于欧洲食品安全局提出的临时每日可耐受摄入量（t-TDI） 4 μ g/kg_bw/d。考虑到年龄依赖性、生物利用度差异，重症监护病房的早产儿体内暴露被认为接近生物有效剂量（BED），将EFSA临时每日总摄入量（t-TDI）转化为等效体内剂量。使用ToxCast21生物途径改变剂量（BPAD）作为替代的内部暴露参考值，与传统的暴露/风险表征方案相比，增加了安全边际。(C) 2016 Elsevier Ltd.版权所有。
The current study aims at a comprehensive risk characterization of bisphenol A (BPA) supported by an integrated exposure modelling framework that comprises far field and near field exposure modelling coupled to a dynamic lifetime PBTK model. Exposure analysis was done on European data of BPA food residues and human biomonitoring (HBM). The latter were further assimilated through an advanced exposure reconstruction modelling framework to estimate the corresponding external and internal systemic dose of BPA and its metabolites. Special attention was paid on the assessment of exposure to BPA during critical developmental stages such as gestation by modelling the mother-fetus toxicokinetic interaction. Our findings showed that current exposure levels in Europe are below the temporary Tolerable Daily Intake (t-TDI) of 4 mu g/kg_bw/d proposed by the European Food Safety Authority. Taking into account age-dependent,bioavailability differences, internal exposure of premature neonates hosted in intensive care units was reckoned close to the biologically effective dose (BED) resulting from translating the EFSA temporary total daily intake (t-TDI) into equivalent internal dose. Use of the ToxCast21 Biological Pathway Altering Dose (BPAD) as an alternative internal exposure reference value, resulted in increased margins of safety compared to the conventional exposure/risk characterization scheme. (C) 2016 Elsevier Ltd. All rights reserved.