Biological subtypes of triple-negative breast cancer are associated with distinct morphological changes and clinical behaviour
Biological subtypes of triple-negative breast cancer are associated with distinct morphological changes and clinical behaviour
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DOI：
10.1016/j.breast.2013.05.012
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发表时间：
2013-10-01
期刊：
影响因子：
3.9
通讯作者：
Aulmann, Sebastian
中科院分区：
文献类型：
--
作者：
Elsawaf, Zeinab;Sinn, Hans-Peter;Aulmann, Sebastian
三阴性乳腺癌（TNBC）是一组异质性肿瘤，约占所有乳腺癌的10-20%。为了鉴定TNBC的生物学上不同的亚组并评估其临床特性，我们检查了一系列142例连续患者，所有患者均使用全面的免疫染色剂接受了辅助细胞毒性化疗。基于13个标志物表达的分层无监督聚类分析允许分离四个不同的组（基底A、基底B、基底管腔、管腔），主要区别特征是细胞角蛋白（Ck 5/6、Ck 14、Ck 19）、EGFR、p53、p16和Ki-67表达。在单因素和多因素分析中，患者年龄、改良的Bloom和Richardson分级、肿瘤坏死、生长模式和生存率的存在不同。基底（A或B）肿瘤的结局明显优于基底腔和腔肿瘤。我们的数据强调了TNBC的异质性，并描述了潜在相关的生物亚型。(C)2013爱思唯尔有限公司保留所有权利。
Triple negative breast cancer (TNBC) is a heterogeneous group of tumours accounting for approximately 10-20% of all breast carcinomas. To identify biologically distinct subgroups of TNBC and to assess their clinical properties we examined a series of 142 consecutive patients all of which had received adjuvant cytotoxic chemotherapy using a comprehensive panel of immunostains. Hierarchical unsupervised cluster analysis based on the expression of 13 markers permitted separation of four distinct groups (basal A, basal B, basoluminal, luminal) with the main distinguishing features being cytokeratin (Ck5/6, Ck14, Ck19), EGFR, p53, p16, and Ki-67 expression. Clusters differed with respect to patient age, modified Bloom and Richardson grading, the presence of tumour necrosis, growth pattern and survival, both in uni- and multivariate analysis. Basal (A or B) tumours showed a substantially better outcome compared with basoluminal and luminal tumours. Our data underline the heterogeneity of TNBC and characterise potentially relevant biological subtypes. (C) 2013 Elsevier Ltd. All rights reserved.