White matter abnormalities in bipolar disorder: insights from diffusion tensor imaging studies
White matter abnormalities in bipolar disorder: insights from diffusion tensor imaging studies
复制标题
DOI：
10.1007/s00702-010-0368-9
复制
发表时间：
2010-05-01
影响因子：
3.3
通讯作者：
Sim, Kang
中科院分区：
文献类型：
--
作者：
Heng, Serene;Song, Allen W.;Sim, Kang
扩散张量成像（DTI）是一种神经影像学技术，具有阐明白色物质异常的潜力。最近，它已被应用于帮助更好地了解双相情感障碍（BD）的病理生理学。本综述旨在综合现有的文献在BD的DTI研究，总结目前的研究结果，并强调大脑区域，一直牵连在BD，以及可能的未来发展方向，在BD的DTI研究。本综述的现有发现表明，白色网络连接丧失可能是与双相情感障碍相关的一种现象，涉及前额叶和额叶区域、投射、联合和连合纤维，稀疏且不太一致的证据表明大脑皮层下和非额叶。在白色物质指数中观察到的变化方向存在一些差异，这些差异可能归因于样本异质性和DTI技术的局限性等因素。顶叶、颞叶、枕叶和皮质下区域在BD中的可能作用有待进一步研究。使用DTI对双相情感障碍的研究落后于其他神经精神疾病，如精神分裂症，但DTI对BD的研究正在快速发展。这些DTI结果的新趋势强调了进一步研究的重要性，以揭示涉及BD中白色物质的潜在神经机制和临床解剖相关性。
Diffusion tensor imaging (DTI) is a neuroimaging technique with the potential to elucidate white matter abnormalities. Recently, it has been applied to help in better understanding of the pathophysiology of bipolar disorder (BD). This review sought to synthesise existing literature on DTI studies in BD, summarise current findings and highlight brain regions that have consistently been implicated in BD, as well as posit possible future directions for DTI research in BD. The extant findings from this review suggest loss of white matter network connectivity as a possible phenomenon associated with bipolar disorder, involving prefrontal and frontal regions, projection, associative and commissural fibres, with sparse and less consistent evidence implicating the subcortical and non-frontal lobes of the brain. There are some differences in the direction of changes observed in white matter indices, and these may be attributed to factors including sample heterogeneity and limitations of DTI techniques. The possible roles of the parietal, temporal and occipital lobes and subcortical regions in BD await further investigation. Studies of bipolar disorder using DTI lag behind other neuropsychiatric diseases such as schizophrenia, but DTI research in BD is fast gaining pace. The emerging trends from these DTI findings underscore the importance of further research to unravel the underlying neural mechanisms and clinico-anatomical correlations involving white matter in BD.