A comparative magnetoencephalographic study of cortical activations evoked by noxious and innocuous somatosensory stimulations
A comparative magnetoencephalographic study of cortical activations evoked by noxious and innocuous somatosensory stimulations
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DOI：
10.1016/s0306-4522(03)00261-6
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发表时间：
2003-01-01
期刊：
影响因子：
3.3
通讯作者：
Kakigi, R
中科院分区：
文献类型：
--
作者：
Inui, K;Tran, TD;Kakigi, R
我们在12名健康志愿者的左手上记录了疼痛的表皮内刺激(ES)和非疼痛的经皮电刺激(TS)产生的体感诱发磁场和电位，以比较皮层对伤害性和非伤害性体感刺激的反应。我们的结果显示，伤害性和非伤害性刺激后的皮层处理非常相似，除了前者比后者延迟约60ms，这可以很好地解释为介导伤害性和无伤害性输入的外周传导速度的差异。ES和TS均可在刺激侧对侧大脑半球的初级躯体感觉皮层(SI)引起首发的皮层活动。在双侧次级躯体感觉皮质(SII)、岛叶皮质、扣带回皮质、前内侧颞区和同侧SI有以下活动。除了ES后岛叶活动的偶极子位于TS后的偶极子之外，两种刺激模式的来源位置没有差异。在潜伏期分别为202和304ms和134和243ms时，ES和TS均可诱发由负波和正波组成的顶点电位。顶端电位的时程与内侧颞区的活动时程一致。结果表明，伤害性刺激和非伤害性刺激在SI和SII的皮层加工相似，但在岛叶皮质不同。我们的数据还表明，杏仁核/海马区的活动代表了伤害性刺激和触觉刺激的共同影响。(C)2003年IBRO。爱思唯尔科学有限公司出版。版权所有。
We recorded somatosensory-evoked magnetic fields and potentials produced by painful intra-epidermal stimulation (ES) and non-painful transcutaneous electrical stimulation (TS) applied to the left hand in 12 healthy volunteers to compare cortical responses to noxious and innocuous somatosensory stimulations. Our results revealed that cortical processing following noxious and innocuous stimulations was strikingly similar except that the former was delayed approximately 60 ms relative to the latter, which was well explained by a difference in peripheral conduction velocity mediating noxious (Adelta fiber) and innocuous (Abeta fiber) inputs. The first cortical activity evoked by both ES and TS was in the primary somatosensory cortex (SI) in the hemisphere contralateral to the stimulated side. The following activities were in the bilateral secondary somatosensory cortex (SII), insular cortex, cingulate cortex, anterior medial temporal area and ipsilateral SI. The source locations did not differ between the two stimulus modalities except that the dipole for insular activity following ES was located more anterior to that following TS. Both ES and TS evoked vertex potentials consisting of a negativity followed by a positivity at a latency of 202 and 304 ms, and 134 and 243 ms, respectively. The time course of the vertex potential corresponded to that of the activity of the medial temporal area. Our results suggested that cortical processing was similar between noxious and innocuous stimulation in SI and SII, but different in insular cortex. Our data also implied that activities in the amygdala/hippocampal formation represented common effects of noxious and tactile stimulations. (C) 2003 IBRO. Published by Elsevier Science Ltd. All rights reserved.