Facile access to highly functionalized hydroisoquinoline derivatives via phosphine-catalyzed sequential [3 3]/[3 3] annulation
Facile access to highly functionalized hydroisoquinoline derivatives via phosphine-catalyzed sequential [3 3]/[3 3] annulation
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通过膦催化的连续[3 3]/[3 3]环化轻松获得高度功能化的氢化异喹啉衍生物
DOI：
10.1039/c9cc05832j
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发表时间：
2019
影响因子：
4.9
通讯作者：
Huang You
中科院分区：
文献类型：
--
作者：
Li Ning;Jia Penghao;Huang You
一种前所未有的由膦催化的联烯酸酯和二烯的连续[3+3]/[3+3]成环反应已经被开发出来，这为获得高度功能化的氢化异喹啉衍生物提供了新颖且简便的途径。该反应具有反应范围宽、反应条件温和的特点。 δ-磺酰胺基联烯酸酯作为五原子单元，代表联烯酸酯反应中的新合成子。
An unprecedented sequential [3+3]/[3+3] annulation of allenoates and dienes catalyzed by phosphine has been developed, which provides novel and facile access to highly functionalized hydroisoquinoline derivatives. The reaction features a wide reaction scope and mild reaction conditions. δ-sulfonamido-allenoates, acting as a five-atom unit, represent a new synthon in the reactions of allenoates.