Immune responses to non-tumor antigens in the central nervous system.
Immune responses to non-tumor antigens in the central nervous system.
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DOI：
10.3389/fonc.2014.00328
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发表时间：
2014
影响因子：
4.7
通讯作者：
Irani DN
中科院分区：
文献类型：
--
作者：
Huber AK;Duncker PC;Irani DN
中枢神经系统（CNS）曾经被视为受血脑屏障（BBB）保护的免疫特权部位，现在已知其是动态免疫环境，免疫细胞通过其迁移以预防和响应诸如局部感染的事件。在这些反应过程中，内源性神经胶质细胞，包括星形胶质细胞和小胶质细胞，变得高度反应性，并可能分泌炎症介质，调节血脑屏障通透性和招募额外的循环免疫细胞。在这里，我们讨论了星形胶质细胞，小胶质细胞和浸润免疫细胞在宿主免疫过程中发挥的各种作用，在中枢神经系统中的非肿瘤抗原，首先集中在细菌和病毒感染，然后转向针对自身抗原的中枢神经系统自身免疫的设置。
The central nervous system (CNS), once viewed as an immune-privileged site protected by the blood–brain barrier (BBB), is now known to be a dynamic immunological environment through which immune cells migrate to prevent and respond to events such as localized infection. During these responses, endogenous glial cells, including astrocytes and microglia, become highly reactive and may secrete inflammatory mediators that regulate BBB permeability and recruit additional circulating immune cells. Here, we discuss the various roles played by astrocytes, microglia, and infiltrating immune cells during host immunity to non-tumor antigens in the CNS, focusing first on bacterial and viral infections, and then turning to responses directed against self-antigens in the setting of CNS autoimmunity.