Mechanisms and functions of lysosome positioning
Mechanisms and functions of lysosome positioning
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DOI：
10.1242/jcs.196287
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发表时间：
2016-12-01
影响因子：
4
通讯作者：
Bonifacino, Juan S.
中科院分区：
文献类型：
--
作者：
Pu, Jing;Guardia, Carlos M.;Bonifacino, Juan S.
溶酶体传统上被认为是终端降解细胞器，但近年来发现它们参与许多其他细胞过程，包括杀死细胞内病原体、抗原呈递、质膜修复、细胞粘附和迁移、肿瘤侵袭和转移、凋亡细胞死亡、代谢信号传导和基因调控。此外，溶酶体功能障碍已被证明不仅是罕见的溶酶体储存障碍的基础，而且是更常见的疾病，如癌症和神经变性。现在已知溶酶体参与大多数这些过程取决于溶酶体在细胞质中移动的能力。在这里，我们回顾了最近的发现介导溶酶体的运动和定位的机制，以及溶酶体动力学对细胞生理和病理的重要性。
Lysosomes have been classically considered terminal degradative organelles, but in recent years they have been found to participate in many other cellular processes, including killing of intracellular pathogens, antigen presentation, plasma membrane repair, cell adhesion and migration, tumor invasion and metastasis, apoptotic cell death, metabolic signaling and gene regulation. In addition, lysosome dysfunction has been shown to underlie not only rare lysosome storage disorders but also more common diseases, such as cancer and neurodegeneration. The involvement of lysosomes in most of these processes is now known to depend on the ability of lysosomes to move throughout the cytoplasm. Here, we review recent findings on the mechanisms that mediate the motility and positioning of lysosomes, and the importance of lysosome dynamics for cell physiology and pathology.