DELAYED PUBERTY FOLLOWING ELECTRICAL STIMULATION OF AMYGDALA IN FEMALE RATS
DELAYED PUBERTY FOLLOWING ELECTRICAL STIMULATION OF AMYGDALA IN FEMALE RATS
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DOI：
10.1152/ajplegacy.1966.211.5.1103
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发表时间：
1966-01-01
影响因子：
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通讯作者：
CRITCHLOW, V
中科院分区：
文献类型：
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作者：
BARSELA, ME;CRITCHLOW, V
24只未成年雌性大鼠通过长期植入电极接受颞叶或下丘脑的每日电刺激。11只大鼠植入了电极，但没有接受电流。将每只实验大鼠的阴道开口年龄与未手术同窝对照大鼠的阴道开口年龄进行比较。9只刺激杏仁复合体皮质内侧区的大鼠和1只在杏仁皮质核植入电极而未接受电刺激的大鼠，阴道开放明显延迟（P < 0.05）。海马结构或下丘脑的刺激没有效果。刺激对阴道张开至排卵的时间和排卵数无明显影响。这些结果支持皮质内侧杏仁核对雌性大鼠青春期的开始起抑制作用的假说。
Twenty-four immature female rats received daily electrical stimulation of the temporal lobes or hypo-thalamus through chronically Implanted electrodes. Eleven rats had electrodes Implanted but received no electric current. Age at vaginal opening of each experimental rat was compared with that of a nonoperated littermate control. Significant (P < 0.05) delay in vaginal opening was observed only in the nine rats stimulated in the cortlcomedlcal division of the amygdaloid complex and in one rat with an electrode implanted in the cortical amygdaloid nucleus which received no electrical stimulation. Stimulation of the hippocampal formation or hypo-thalamus were without effect. The Interval between vaginal opening and ovulation and the number of ova shed were not affected by stimulation. These results support the hypothesis that the corticomedlal amygdala exerts an inhibitory Influence on the onset of puberty in the female rat.