MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
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DOI：
10.1016/s1097-2765(00)80136-7
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发表时间：
1998-08-01
期刊：
影响因子：
16
通讯作者：
Janeway, CA
中科院分区：
文献类型：
--
作者：
Medzhitov, R;Preston-Hurlburt, P;Janeway, CA
使用NF-kappa B途径的Toll介导的信号级联已被证明对成年果蝇的免疫应答至关重要，我们最近报道了果蝇Toll蛋白的人类同源物通过该途径诱导各种免疫应答基因。我们现在证明，人类Toll受体的信号传导使用一种接头蛋白MyD88，并通过球样激酶IRAK和TRAF6蛋白诱导NF-kappa B的激活，类似于il - 1r介导的NF-kappa B激活。然而，我们发现Toll和IL-1R信号通路在AP-1激活方面并不相同。最后，我们的研究结果表明MyD88是先天免疫中Toll/IL-1R受体家族的一般适配器/调节分子。
The Toll-mediated signaling cascade using the NF-kappa B pathway has been shown to be essential for immune responses in adult Drosophila, and we recently reported that a human homolog of the Drosophila Toll protein induces various immune response genes via this pathway. We now demonstrate that signaling by the human Toll receptor employs an adaptor protein, MyD88, and induces activation of NF-kappa B via the Pelle-like kinase IRAK and the TRAF6 protein, similar to IL-1R-mediated NF-kappa B activation. However, we find that Toll and IL-1R signaling pathways are not identical with respect to AP-1 activation. Finally, our findings implicate MyD88 as a general adaptor/regulator molecule for the Toll/IL-1R family of receptors for innate immunity.